Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/117579
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dc.contributor.authorVan Ly, D.en
dc.contributor.authorLow, R.en
dc.contributor.authorFrölich, S.en
dc.contributor.authorBartolec, T.en
dc.contributor.authorKafer, G.en
dc.contributor.authorPickett, H.en
dc.contributor.authorGaus, K.en
dc.contributor.authorCesare, A.en
dc.date.issued2018en
dc.identifier.citationMolecular Cell, 2018; 71(4):510-525en
dc.identifier.issn1097-2765en
dc.identifier.issn1097-4164en
dc.identifier.urihttp://hdl.handle.net/2440/117579-
dc.description.abstractTelomeres regulate DNA damage response (DDR) and DNA repair activity at chromosome ends. How telomere macromolecular structure contributes to ATM regulation and its potential dissociation from control over non-homologous end joining (NHEJ)-dependent telomere fusion is of central importance to telomere-dependent cell aging and tumor suppression. Using super-resolution microscopy, we identify that ATM activation at mammalian telomeres with reduced TRF2 or at human telomeres during mitotic arrest occurs specifically with a structural change from telomere loops (t-loops) to linearized telomeres. Additionally, we find the TRFH domain of TRF2 regulates t-loop formation while suppressing ATM activity. Notably, we demonstrate that ATM activation and telomere linearity occur separately from telomere fusion via NHEJ and that linear DDR-positive telomeres can remain resistant to fusion, even during an extended G1 arrest, when NHEJ is most active. Collectively, these results suggest t-loops act as conformational switches that specifically regulate ATM activation independent of telomere mechanisms to inhibit NHEJ.en
dc.description.statementofresponsibilityDavid Van Ly, Ronnie Ren Jie Low, Sonja Frölich, Tara K.Bartolec, Georgia R.Kafer, Hilda A.Pickett, Katharina Gaus, Anthony J.Cesareen
dc.language.isoenen
dc.publisherCell Pressen
dc.rights© 2018 Elsevier Inc.en
dc.subjectATM; Aurora B kinase; DNA damage response; TRF2; mitosis; non-homologous end joining; super-resolution microscopy; telomere loops; telomere protection; telomeresen
dc.titleTelomere loop dynamics in chromosome end protectionen
dc.typeJournal articleen
dc.identifier.rmid0030095377en
dc.identifier.doi10.1016/j.molcel.2018.06.025en
dc.relation.granthttp://purl.org/au-research/grants/arc/CE140100011en
dc.relation.granthttp://purl.org/au-research/grants/arc/LP140100967en
dc.relation.granthttp://purl.org/au-research/grants/arc/LE150100163en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1059278en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1037320en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1053195en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1106241en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1104461en
dc.identifier.pubid431263-
pubs.library.collectionGenetics publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Genetics publications

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