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https://hdl.handle.net/2440/117650
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Type: | Journal article |
Title: | The mGlu5 receptor antagonist MTEP attenuates opiate self-administration and cue-induced opiate-seeking behaviour in mice |
Author: | Brown, R.M. Stagnitti, M.R. Duncan, J.R. Lawrence, A.J. |
Citation: | Drug and Alcohol Dependence, 2012; 123(1-3):264-268 |
Publisher: | Elsevier |
Issue Date: | 2012 |
ISSN: | 0376-8716 1879-0046 |
Statement of Responsibility: | Robyn M.Brown, Monique R.Stagnitti, Jhodie R.Duncan, Andrew J.Lawrence |
Abstract: | The mGlu5 receptor (mGluR5) has been implicated in the rewarding effect of various drugs of abuse and drug-seeking behaviour. In the present study we investigated the impact of antagonism of mGluR5 with the selective negative allosteric, modulator 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) on operant self-administration of morphine as well as cue-induced drug-seeking in adult CD1 mice. Administration of MTEP (20 mg/kg, i.p.) attenuated operant responding for morphine (0.1 mg/kg/infusion) and cue-induced morphine-seeking after a period of forced abstinence. Collectively, these data implicate mGluR5 in the reinforcing effects of opiates and support the proposition that mGluR5 is a potential therapeutic target for treatment of drug addiction. |
Keywords: | Reinstatement; morphine; intra-venous self-administration; drug-seeking; MGluR5; opiates; relapse |
Rights: | © 2011 Elsevier Ireland Ltd. All rights reserved. |
DOI: | 10.1016/j.drugalcdep.2011.11.002 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/566736 |
Published version: | http://dx.doi.org/10.1016/j.drugalcdep.2011.11.002 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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