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Type: Journal article
Title: Translating evidence of HDL and plaque regression
Author: Di Bartolo, B.
Psaltis, P.
Bursill, C.
Nicholls, S.
Citation: Arteriosclerosis, thrombosis, and vascular biology, 2018; 38(9):1961-1968
Publisher: Lippincott Williams & Wilkins
Issue Date: 2018
ISSN: 1079-5642
Statement of
Belinda A. Di Bartolo, Peter J. Psaltis, Christina A. Bursill, Stephen J. Nicholls
Abstract: Considerable evidence from preclinical and population studies suggests that HDLs (high-density lipoproteins) possess atheroprotective properties. Reports from HDL infusion studies in animals and early clinical imaging trials reported evidence of plaque regression. These findings have stimulated further interest in developing new agents targeting HDL. However, the results of more recent imaging studies in the setting of high-intensity statin use have been disappointing. As the concept of plaque changes with HDL therapeutics evolves and imaging technology to evaluate these effects advances, there will become increasing opportunity to determine the effects of HDL agents on atherosclerotic plaque (Graphic Abstract).
Keywords: animals; atherosclerosis; lipids; research; risk factors
Rights: © 2018 American Heart Association, Inc.
RMID: 0030099441
DOI: 10.1161/ATVBAHA.118.307026
Appears in Collections:Medicine publications

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