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Type: Journal article
Title: Urine-derived cells for human cell therapy
Author: Pavathuparambil Abdul Manaph, N.
Al-Hawaas, M.
Bobrovskaya, L.
Coates, P.
Zhou, X.
Citation: Stem Cell Research and Therapy, 2018; 9(1):189-1-189-12
Publisher: BMC
Issue Date: 2018
ISSN: 1757-6512
Statement of
Nimshitha Pavathuparambil Abdul Manaph, Mohammed Al-Hawwas, Larisa Bobrovskaya, Patrick T. Coates and Xin-Fu Zhou
Abstract: Desirable cells for human cell therapy would be ones that can be generated by simple isolation and culture techniques using a donor sample obtained by non-invasive methods. To date, the different donor-specific cells that can be isolated from blood, skin, and hair require invasive methods for sample isolation and incorporate complex and costly reagents to culture. These cells also take considerable time for their in-vitro isolation and expansion. Previous studies suggest that donor-derived cells, namely urine stem cells and renal cells, may be isolated from human urine samples using a cost-effective and simple method of isolation, incorporating not such complex reagents. Moreover, the isolated cells, particularly urine stem cells, are superior to conventional stem cell sources in terms of favourable gene profile and inherent multipotent potential. Transdifferentiation or differentiation of human urine-derived cells can generate desirable cells for regenerative therapy. In this review, we intended to discuss the characteristics and therapeutic applications of urine-derived cells for human cell therapy. Conclusively, with detailed study and optimisation, urine-derived cells have a prospective future to generate functional lineage-specific cells for patients from a clinical translation point of view.
Keywords: Differentiation; Renal cells; Stem cells; Therapy; Urine
Description: Corrected by: Correction to: Urine-derived cells for human cell therapy (Stem Cell Res Ther. (2018) 9 (189) DOI: 10.1186/s13287-018-0932-z). The original article [1] contained a small typo affecting the co-author, Mohammed Al-Hawwas's name. This error has now been corrected.
Rights: © The Author(s). 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
RMID: 0030095492
DOI: 10.1186/s13287-018-0932-z
Appears in Collections:Medicine publications

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