Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/117829
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dc.contributor.authorYousefi, M.en
dc.contributor.authorPourmehran, O.en
dc.contributor.authorGorji-Bandpy, M.en
dc.contributor.authorInthavong, K.en
dc.contributor.authorYeo, L.en
dc.contributor.authorTu, J.en
dc.date.issued2017en
dc.identifier.citationBiomechanics and Modeling in Mechanobiology, 2017; 16(6):2035-2050en
dc.identifier.issn1617-7959en
dc.identifier.issn1617-7940en
dc.identifier.urihttp://hdl.handle.net/2440/117829-
dc.description.abstractAdministration of drug in the form of particles through inhalation is generally preferable in the treatment of respiratory disorders. Conventional inhalation therapy devices such as inhalers and nebulizers, nevertheless, suffer from low delivery efficiencies, wherein only a small fraction of the inhaled drug reaches the lower respiratory tract. This is primarily because these devices are not able to produce a sufficiently fine drug mist that has aerodynamic diameters on the order of a few microns. This study employs computational fluid dynamics to investigate the transport and deposition of the drug particles produced by a new aerosolization technique driven by surface acoustic waves (SAWs) into an in silico lung model geometrically reconstructed using computed tomography scanning. The particles generated by the SAW are released in different locations in a spacer chamber attached to a lung model extending from the mouth to the 6th generation of the lung bronchial tree. An Eulerian approach is used to solve the Navier-Stokes equations that govern the airflow within the respiratory tract, and a Lagrangian approach is adopted to track the particles, which are assumed to be spherical and inert. Due to the complexity of the lung geometry, the airflow patterns vary as it penetrates deeper into the lung. High inertia particles tend to deposit at locations where the geometry experiences a significant reduction in cross section. Our findings, nevertheless, show that the injection location can influence the delivery efficiency: Injection points close to the spacer centerline result in deeper penetration into the lung. Additionally, we found that the ratio of drug particles entering the right lung is significantly higher than the left lung, independent of the injection location. This is in good agreement with this fact that the most of airflow enters to the right lobes.en
dc.description.statementofresponsibilityMorteza Yousefi, Oveis Pourmehran, Mofid Gorji-Bandpy, Kiao Inthavong, Leslie Yeo, Jiyuan Tuen
dc.language.isoenen
dc.publisherSpringer-Verlagen
dc.rights© Springer-Verlag GmbH Germany 2017en
dc.subjectComputational fluid dynamics; surface acoustic wave; nebulizer; Lung; Aerosol; drug deliveryen
dc.titleCFD simulation of aerosol delivery to a human lung via surface acoustic wave nebulizationen
dc.typeJournal articleen
dc.identifier.rmid0030076233en
dc.identifier.doi10.1007/s10237-017-0936-0en
dc.relation.granthttp://purl.org/au-research/grants/arc/FT130100672en
dc.identifier.pubid371061-
pubs.library.collectionMechanical Engineering publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Mechanical Engineering publications

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