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dc.contributor.authorLiang, W.en
dc.contributor.authorXu, H.en
dc.contributor.authorCarraro, F.en
dc.contributor.authorMaddigan, N.en
dc.contributor.authorLi, Q.en
dc.contributor.authorBell, S.en
dc.contributor.authorHuang, D.en
dc.contributor.authorTarzia, A.en
dc.contributor.authorSolomon, M.en
dc.contributor.authorAmenitsch, H.en
dc.contributor.authorVaccari, L.en
dc.contributor.authorSumby, C.en
dc.contributor.authorFalcaro, P.en
dc.contributor.authorDoonan, C.en
dc.identifier.citationJournal of the American Chemical Society, 2019; 141(6):2348-2355en
dc.description.abstractEncapsulation of biomacromolecules in metal-organic frameworks (MOFs) can preserve biological functionality in harsh environments. Despite the success of this approach, termed biomimietic mineralization, limited consideration has been given to the chemistry of the MOF coating. Here, we show that enzymes encapsulated within hydrophilic MAF-7 or ZIF-90 retain enzymatic activity upon encapsulation and when exposed to high temperatures, denaturing or proteolytic agents, and organic solvents, whereas hydrophobic ZIF-8 affords inactive catalase and negligible protection to urease.en
dc.description.statementofresponsibilityWeibin Liang, Huoshu Xu, Francesco Carraro, Natasha K. Maddigan, Qiaowei Li, Stephen G. Bell, David M. Huang, Andrew Tarzia, Marcello B. Solomon, Heinz Amenitsch, Lisa Vaccari, Christopher J. Sumby, Paolo Falcaro, and Christian J. Doonanen
dc.publisherAmerican Chemical Societyen
dc.rightsCopyright: Published 2019 by the American Chemical Societyen
dc.titleEnhanced activity of enzymes encapsulated in hydrophilic metal-organic frameworksen
dc.typeJournal articleen
pubs.library.collectionChemistry publicationsen
dc.identifier.orcidBell, S. [0000-0002-7457-9727]en
dc.identifier.orcidHuang, D. [0000-0003-2048-4500]en
dc.identifier.orcidSolomon, M. [0000-0003-0732-676X]en
dc.identifier.orcidSumby, C. [0000-0002-9713-9599]en
Appears in Collections:Chemistry publications

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