Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/118348
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dc.contributor.authorHassanshahi, M.en
dc.contributor.authorSu, Y.en
dc.contributor.authorFan, C.en
dc.contributor.authorKhabbazi, S.en
dc.contributor.authorHassanshahi, A.en
dc.contributor.authorXian, C.en
dc.date.issued2019en
dc.identifier.citationJournal of Cellular Biochemistry, 2019; 120(3):3220-3231en
dc.identifier.issn0730-2312en
dc.identifier.issn1097-4644en
dc.identifier.urihttp://hdl.handle.net/2440/118348-
dc.description.abstractChemotherapeutic agents are very well evident extrinsic stimuli for causing damage to endothelial cells. Methotrexate is an antimetabolite commonly used to treat solid tumours and paediatric cancers. However, studies on the effect(s) of methotrexate on bone marrow microvascular system are inadequate. In the current study, we observed a significant bone marrow microvascular dilation following methotrexate therapy in rats, accompanied by apoptosis induction in bone marrow sinusoidal endothelial cells, and followed by recovery of bone marrow sinusoids associated with increased proliferation of remaining bone marrow sinusoidal endothelial cells. Our in vitro studies revealed that methotrexate is cytotoxic for cultured sinusoidal endothelial cells and can also induce apoptosis which is associated with upregulation of expression ratio of Bax and Bcl‐2 genes and Bax/Bcl‐2 expression ratio. Furthermore, it was shown that methotrexate can negatively affect proliferation of cultured sinusoidal endothelial cells and also inhibit their abilities of migration and formation of microvessel like tubes. The data from this study indicates that methotrexate can cause significant bone marrow sinusoidal endothelium damage in vivo and induce apoptosis and inhibit proliferation, migration and tube‐forming abilities of sinusoidal endothelial cells in vitro.en
dc.description.statementofresponsibilityMohammadhossein Hassanshahi, Yu‐Wen Su, Chia‐Ming Fan, Samira Khabbazi, Alireza Hassanshahi, Cory J. Xianen
dc.language.isoenen
dc.publisherWileyen
dc.rights© 2018 Wiley Periodicals, Inc.en
dc.subjectAngiogenesis; apoptosis; bone marrow sinusoidal endothelial cells; bone marrow sinusoids; methotrexateen
dc.titleMethotrexate chemotherapy–induced damages in bone marrow sinusoids: an in vivo and in vitro studyen
dc.typeJournal articleen
dc.identifier.rmid0030102904en
dc.identifier.doi10.1002/jcb.27589en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1042105en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1127396en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/508046en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/508047en
dc.identifier.pubid438407-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidXian, C. [0000-0002-8467-2845]en
Appears in Collections:Medicine publications

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