Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Relationship between allograft cyclosporin concentrations and P-glycoprotein expression in the 1st month following renal transplantation|
|Citation:||British Journal of Clinical Pharmacology, 2019; 85(5):1015-1020|
|Publisher:||British Pharmacological Society|
|Benedetta C. Sallustio, Benjamin D. Noll, Janet K. Coller, Jonathan Tuke Graeme Russ, Andrew A. Somogyi|
|Abstract:||The immunosuppressant cyclosporin is a P-glycoprotein (P-gp) substrate whose impaired function has been associated with an increased risk of cyclosporin-induced nephrotoxicity following renal transplantation. This study investigated the relationship between blood and allograft cyclosporin concentration, and the effect of P-gp expression. Fifty biopsy samples were obtained from 39 renal transplant recipients who received cyclosporin as part of maintenance immunosuppression. Blood cyclosporin concentrations (2 hours postdose) were obtained from clinical records, matching allograft cyclosporin concentrations were measured in frozen biopsy tissue by liquid chromatography-tandem mass spectrometry, and allograft P-gp expression was assessed by immunohistochemistry. Blood and allograft cyclosporin concentrations in the 1st month post-transplantation ranged from 505-2005 μg/L and 0.01-16.7 ng/mg tissue, respectively. Dose was the only significant predictor of allograft cyclosporin concentrations (adjusted R2 = .24, F-statistic = 11.52, P = .0019), with no effect of P-gp expression or blood cyclosporin concentrations. P-gp expression is not the major determinant of allograft cyclosporin concentrations.|
|Keywords:||P-glycoprotein; allograft concentrations; cyclosporin; kidney transplantation|
|Rights:||© 2019 The British Pharmacological Society|
|Appears in Collections:||Pharmacology publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.