Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/118417
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Type: Journal article
Title: Opposite fates of the purine metabolite allantoin under water and nitrogen limitations in bread wheat
Author: Casartelli, A.
Melino, V.
Baumann, U.
Riboni, M.
Suchecki, R.
Jayasinghe, N.
Mendis, H.
Watanabe, M.
Erban, A.
Zuther, E.
Hoefgen, R.
Roessner, U.
Okamoto, M.
Heuer, S.
Citation: Plant Molecular Biology, 2019; 99(4-5):477-497
Publisher: Springer
Issue Date: 2019
ISSN: 0167-4412
1573-5028
Statement of
Responsibility: 
Alberto Casartelli, Vanessa J. Melino, Ute Baumann, Matteo Riboni, Radoslaw Suchecki, Nirupama S. Jayasinghe, Himasha Mendis, Mutsumi Watanabe, Alexander Erban, Ellen Zuther, Rainer Hoefgen, Ute Roessner, Mamoru Okamoto, Sigrid Heuer
Abstract: KEY MESSAGE:Degradation of nitrogen-rich purines is tightly and oppositely regulated under drought and low nitrogen supply in bread wheat. Allantoin is a key target metabolite for improving nitrogen homeostasis under stress. The metabolite allantoin is an intermediate of the catabolism of purines (components of nucleotides) and is known for its housekeeping role in nitrogen (N) recycling and also for its function in N transport and storage in nodulated legumes. Allantoin was also shown to differentially accumulate upon abiotic stress in a range of plant species but little is known about its role in cereals. To address this, purine catabolic pathway genes were identified in hexaploid bread wheat and their chromosomal location was experimentally validated. A comparative study of two Australian bread wheat genotypes revealed a highly significant increase of allantoin (up to 29-fold) under drought. In contrast, allantoin significantly decreased (up to 22-fold) in response to N deficiency. The observed changes were accompanied by transcriptional adjustment of key purine catabolic genes, suggesting that the recycling of purine-derived N is tightly regulated under stress. We propose opposite fates of allantoin in plants under stress: the accumulation of allantoin under drought circumvents its degradation to ammonium (NH4+) thereby preventing N losses. On the other hand, under N deficiency, increasing the NH4+ liberated via allantoin catabolism contributes towards the maintenance of N homeostasis.
Keywords: Allantoin; Drought; Nitrogen deficiency; Nutrient recycling; Purine catabolism; Triticum aestivum
Rights: © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
RMID: 0030108211
DOI: 10.1007/s11103-019-00831-z
Grant ID: http://purl.org/au-research/grants/arc/LP140100239
Appears in Collections:Agriculture, Food and Wine publications

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