Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/118447
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dc.contributor.authorOtieno, L.A.-
dc.contributor.authorOpie, G.-
dc.contributor.authorSemmler, J.-
dc.contributor.authorRidding, M.-
dc.contributor.authorSidhu, S.-
dc.date.issued2019-
dc.identifier.citationJournal of Neurophysiology, 2019; 121(2):471-479-
dc.identifier.issn0022-3077-
dc.identifier.issn1522-1598-
dc.identifier.urihttp://hdl.handle.net/2440/118447-
dc.description.abstractFatiguing intermittent single-joint exercise causes an increase in corticospinal excitability and a decrease in intracortical inhibition when measured with peripherally recorded motor evoked potentials (MEPs) after transcranial magnetic stimulation (TMS). Combined TMS and electroencephalography (TMS-EEG) allows for more direct recording of cortical responses through the TMS-evoked potential (TEP). The aim of this study was to investigate the changes in the excitatory and inhibitory components of the TEP during fatiguing single-joint exercise. Twenty-three young (22 ± 2 yr) healthy subjects performed intermittent 30-s maximum voluntary contractions of the right first dorsal interosseous muscle, followed by a 30-s relaxation period repeated for a total of 15 min. Six single-pulse TMSs and one peripheral nerve stimulation (PNS) to evoke maximal M wave (Mmax) were applied during each relaxation period. A total of 90 TMS pulses and 5 PNSs were applied before and after fatiguing exercise to record MEP and TEP. The amplitude of the MEP (normalized to Mmax) increased during fatiguing exercise ( P < 0.001). There were no changes in local and global P30, N45, and P180 of TEPs during the development of intermittent single-joint exercise-induced fatigue. Global analysis, however, revealed a decrease in N100 peak of the TEP during fatiguing exercise compared with before fatiguing exercise ( P = 0.02). The decrease in N100 suggests a fatigue-related decrease in global intracortical GABAB-mediated inhibition. The increase in corticospinal excitability typically observed during single-joint fatiguing exercise may be mediated by a global decrease in intracortical inhibition. NEW & NOTEWORTHY Fatiguing intermittent single-joint exercise causes an increase in corticospinal excitability and a decrease in intracortical inhibition when measured with transcranial magnetic stimulation (TMS)-evoked potentials from the muscle. The present study provides new and direct cortical evidence, using TMS-EEG to demonstrate that during single-joint fatiguing exercise there is a global decrease in intracortical GABAB-mediated inhibition.-
dc.description.statementofresponsibilityLavender A. Otieno, George M. Opie, John G. Semmler, Michael C. Ridding and Simranjit K. Sidhu-
dc.language.isoen-
dc.publisherAmerican Physiological Society-
dc.rights© 2019 the American Physiological Society-
dc.source.urihttp://dx.doi.org/10.1152/jn.00628.2018-
dc.subjectTMS-EEG-
dc.subjectcortical excitability-
dc.subjectcortical inhibition-
dc.subjectfatigue-
dc.titleIntermittent single-joint fatiguing exercise reduces TMS-EEG measures of cortical inhibition-
dc.typeJournal article-
dc.identifier.doi10.1152/jn.00628.2018-
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1139723-
pubs.publication-statusPublished-
dc.identifier.orcidOtieno, L.A. [0000-0001-6312-9088]-
dc.identifier.orcidOpie, G. [0000-0001-7771-7569]-
dc.identifier.orcidSemmler, J. [0000-0003-0260-8047]-
dc.identifier.orcidRidding, M. [0000-0001-5657-9136]-
dc.identifier.orcidSidhu, S. [0000-0002-4797-8298]-
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