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Type: Journal article
Title: Association between multimorbidity and undiagnosed obstructive sleep apnea severity and their impact on quality of life in men over 40 years old
Author: Ruel, G.
Martin, S.
Lévesque, J.-.F.
Wittert, G.
Adams, R.
Appleton, S.
Shi, Z.
Taylor, A.
Citation: Global Health, Epidemiology and Genomics, 2018; 3:e10
Publisher: Cambridge University Press (CUP)
Issue Date: 2018
ISSN: 2054-4200
Statement of
G. Ruel, S. A. Martin, J.-F. Lévesque, G. A. Wittert, R. J. Adams, S. L. Appleton, Z. Shi and A. W. Taylor
Abstract: Background:Multimorbidity is common but little is known about its relationship with obstructive sleep apnea (OSA). Methods:Men Androgen Inflammation Lifestyle Environment and Stress Study participants underwent polysomnography. Chronic diseases (CDs) were determined by biomedical measurement (diabetes, dyslipidaemia, hypertension, obesity), or self-report (depression, asthma, cardiovascular disease, arthritis). Associations between CD count, multimorbidity, apnea-hyponea index (AHI) and OSA severity and quality-of-life (QoL; mental & physical component scores), were determined using multinomial regression analyses, after adjustment for age. Results:Of the 743 men participating in the study, overall 58% had multimorbidity (2+ CDs), and 52% had OSA (11% severe). About 70% of those with multimorbidity had undiagnosed OSA. Multimorbidity was associated with AHI and undiagnosed OSA. Elevated CD count was associated with higher AHI value and increased OSA severity. Conclusion:We demonstrate an independent association between the presence of OSA and multimorbidity in this representative sample of community-based men. This effect was strongest in men with moderate to severe OSA and three or more CDs, and appeared to produce a greater reduction in QoL when both conditions were present together.
Keywords: Apnea-hypopnea index; chronic disease; comorbidity; obstructive sleep apnea; quality of life
Rights: © The Author(s) 2018 This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (, which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
RMID: 0030099335
DOI: 10.1017/gheg.2018.9
Appears in Collections:Medicine publications

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