Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/118735
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Type: Journal article
Title: Associations between the cyclooxygenase-2 expression in circulating tumor cells and the clinicopathological features of patients with colorectal cancer
Author: Cai, J.
Huang, L.
Huang, J.
Kang, L.
Lin, H.
Huang, P.
Zhu, P.
Wang, J.
Dong, J.
Wang, L.
Xian, C.
Citation: Journal of Cellular Biochemistry, 2019; 120(4):4935-4941
Publisher: Wiley
Issue Date: 2019
ISSN: 0730-2312
1097-4644
Statement of
Responsibility: 
Jinlin Cai, Liang Huang, Jun Huang, Liang Kang, Hongcheng Lin ... Cory J. Xian ... et al.
Abstract: While previous studies have shown that the number of circulating tumor cells (CTCs) alone is not sufficient to reflect tumor progression and that cyclooxygenase-2 (COX-2) expression is correlated with colorectal cancer (CRC) metastasis, COX-2 expression status and its potential functions in CTCs of CRC patients are unknown. Here, epithelial-mesenchymal transition (EMT) phenotype-based subsets of CTCs and the COX-2 expression status in CTCs were identified and their potential clinical values were assessed in 91 CRC patients. CTCs were enumerated in peripheral blood and subsets of CTCs (epithelial [eCTCs], mesenchymal [mCTCs], and biophenotypic [bCTCs]) and the COX-2 expression status were determined using the RNA in situ hybridization method. CTCs were detected in 80.2% (73 of 91) patients. Neither the total CTC nor eCTC numbers were found to significantly associate with any of the clinicopathological features. However, the number of mCTCs was significantly associated with distance metastasis (P = 0.035) and had a trend of being associated with lymph node metastasis ( P = 0.055). Among the 73 patients enrolled for evaluating COX-2 expression, 52.5% (38 of 73) were found to express COX-2 in CTCs, and COX-2 expression in CTCs was not found to associate with the clinicopathological factors. However, COX-2 expression in mCTCs tended to have a higher rate in patients with metastasis compared with those without metastasis (72.0% vs 42.8%; P = 0.072). Furthermore, COX-2 expression and mCTC marker expression correlated positively ( R = 0.287; P = 0.017). Further studies are required to investigate the clinical value of the expression of COX-2 in mCTCs, especially in CRC patients with the advanced tumor stage and distant metastasis.
Keywords: COX-2; circulating tumor cells; colorectal cancer; epithelial-mesenchymal transition
Rights: © 2018 Wiley Periodicals, Inc.
RMID: 0030102908
DOI: 10.1002/jcb.27768
Appears in Collections:Medicine publications

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