Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/118809
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Type: Journal article
Title: Autophagy-dependent cell death
Author: Denton, D.
Kumar, S.
Citation: Cell Death and Differentiation, 2019; 26(4):605-616
Publisher: Nature Publishing Group
Issue Date: 2019
ISSN: 1350-9047
1476-5403
Statement of
Responsibility: 
Donna Denton and Sharad Kumar
Abstract: Autophagy-dependent cell death can be defined as cell demise that has a strict requirement of autophagy. Although autophagy often accompanies cell death following many toxic insults, the requirement of autophagic machinery for cell death execution, as established through specific genetic or chemical inhibition of the process, is highly contextual. During animal development, perhaps the best validated model of autophagy-dependent cell death is the degradation of the larval midgut during larval-pupal metamorphosis, where a number of key autophagy genes are required for the removal of the tissues. Surprisingly though, even in the midgut, not all of the 'canonical' autophagic machinery appears to be required. In other organisms and cancer cells many variations of autophagy-dependent cell death are apparent, pointing to the lack of a unifying cell death pathway. It is thus possible that components of the autophagy machinery are selectively utilised or repurposed for this type of cell death. In this review, we discuss examples of cell death that utilise autophagy machinery (or part thereof), the current knowledge of the complexity of autophagy-dependent cellular demise and the potential mechanisms and regulatory pathways involved in such cell death.
Rights: © ADMC Associazione Differenziamento e Morte Cellulare 2018
RMID: 0030106135
DOI: 10.1038/s41418-018-0252-y
Grant ID: http://purl.org/au-research/grants/nhmrc/1124490
http://purl.org/au-research/grants/nhmrc/1103006
http://purl.org/au-research/grants/arc/DP170100623
Appears in Collections:Medicine publications

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