Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/118994
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Type: Journal article
Title: A meta-analysis of echocardiographic measurements of the left heart for the development of normative reference ranges in a large international cohort: the EchoNoRMAL study
Author: Doughty, R.
Gardin, J.
Hobbs, F.
McMurray, J.
Nagueh, S.
Poppe, K.
Senior, R.
Thomas, L.
Whalley, G.
Aune, E.
Brown, A.
Badano, L.
Cameron, V.
Chadha, D.
Chahal, N.
Chien, K.
Daimon, M.
Dalen, H.
Detrano, R.
Duzenli, M.A.
et al.
Citation: European Heart Journal - Cardiovascular Imaging, 2014; 15(3):341-348
Publisher: Oxford University Press
Issue Date: 2014
ISSN: 2047-2404
2047-2412
Statement of
Responsibility: 
R.N. Doughty, J.M. Gardin, F.D.R. Hobbs, J.J. V. McMurray, S.F. Nagueh … Alexander Brown … et al. The Echocardiographic Normal Ranges Meta-Analysis of the Left heart (EchoNoRMAL) Collaboration
Abstract: Aim: To develop age-, sex-, and ethnic-appropriate normative reference ranges for standard echocardiographic measurements of the left heart by combining echocardiographic measurements obtained from adult volunteers without clinical cardiovascular disease or significant cardiovascular risk factors, from multiple studies around the world. Methods and results: The Echocardiographic Normal Ranges Meta-Analysis of the Left heart (EchoNoRMAL) collaboration was established and population-based data sets of echocardiographic measurements combined to perform an individual person data meta-analysis. Data from 43 studies were received, representing 51 222 subjects, of which 22 404 adults aged 18–80 years were without clinical cardiovascular or renal disease, hypertension or diabetes. Quantile regression or an appropriate parametric regression method will be used to derive reference values at the 5th and 95th centile of each measurement against age. Conclusion: This unique data set represents a large, multi-ethnic cohort of subjects resident in a wide range of countries. The resultant reference ranges will have wide applicability for normative data based on age, sex, and ethnicity.
Keywords: Echocardiography; reference ranges; meta-analysis
Rights: Published on behalf of the European Society of Cardiology. All rights reserved. &The Author 2013.
RMID: 0030099279
DOI: 10.1093/ehjci/jet240
Appears in Collections:Medicine publications

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