Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/119015
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Characterisation of major histocompatibility complex class I transcripts in an Australian dragon lizard |
Author: | Hacking, J. Bertozzi, T. Moussalli, A. Bradford, T. Gardner, M. |
Citation: | Developmental and Comparative Immunology, 2018; 84:164-171 |
Publisher: | Elsevier |
Issue Date: | 2018 |
ISSN: | 0145-305X 1879-0089 |
Statement of Responsibility: | Jessica Hacking, Terry Bertozzi, Adnan Moussalli, Tessa Bradford, Michael Gardner |
Abstract: | Characterisation of squamate major histocompatibility complex (MHC) genes has lagged behind other taxonomic groups. MHC genes encode cell-surface glycoproteins that present self- and pathogen-derived peptides to T cells and play a critical role in pathogen recognition. Here we characterise MHC class I transcripts for an agamid lizard (Ctenophorus decresii) and investigate the evolution of MHC class I in Iguanian lizards. An iterative assembly strategy was used to identify six full-length C. decresii MHC class I transcripts, which were validated as likely to encode classical class I MHC molecules. Evidence for exon shuffling recombination was uncovered for C. decresii transcripts and Bayesian phylogenetic analysis of Iguanian MHC class I sequences revealed a pattern expected under a birth-and-death mode of evolution. This work provides a stepping stone towards further research on the agamid MHC class I region. |
Keywords: | Transcriptome assembly; Iguania; Agamidae; Ctenophorus decresii; MHC class I evolution |
Rights: | © 2018 Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.dci.2018.02.012 |
Published version: | http://dx.doi.org/10.1016/j.dci.2018.02.012 |
Appears in Collections: | Aurora harvest 4 Ecology, Evolution and Landscape Science publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.