Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/119015
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DC Field | Value | Language |
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dc.contributor.author | Hacking, J. | - |
dc.contributor.author | Bertozzi, T. | - |
dc.contributor.author | Moussalli, A. | - |
dc.contributor.author | Bradford, T. | - |
dc.contributor.author | Gardner, M. | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Developmental and Comparative Immunology, 2018; 84:164-171 | - |
dc.identifier.issn | 0145-305X | - |
dc.identifier.issn | 1879-0089 | - |
dc.identifier.uri | http://hdl.handle.net/2440/119015 | - |
dc.description.abstract | Characterisation of squamate major histocompatibility complex (MHC) genes has lagged behind other taxonomic groups. MHC genes encode cell-surface glycoproteins that present self- and pathogen-derived peptides to T cells and play a critical role in pathogen recognition. Here we characterise MHC class I transcripts for an agamid lizard (Ctenophorus decresii) and investigate the evolution of MHC class I in Iguanian lizards. An iterative assembly strategy was used to identify six full-length C. decresii MHC class I transcripts, which were validated as likely to encode classical class I MHC molecules. Evidence for exon shuffling recombination was uncovered for C. decresii transcripts and Bayesian phylogenetic analysis of Iguanian MHC class I sequences revealed a pattern expected under a birth-and-death mode of evolution. This work provides a stepping stone towards further research on the agamid MHC class I region. | - |
dc.description.statementofresponsibility | Jessica Hacking, Terry Bertozzi, Adnan Moussalli, Tessa Bradford, Michael Gardner | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | © 2018 Elsevier Ltd. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.dci.2018.02.012 | - |
dc.subject | Transcriptome assembly; Iguania; Agamidae; Ctenophorus decresii; MHC class I evolution | - |
dc.title | Characterisation of major histocompatibility complex class I transcripts in an Australian dragon lizard | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.dci.2018.02.012 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Bertozzi, T. [0000-0001-6665-3395] | - |
dc.identifier.orcid | Bradford, T. [0000-0003-0607-1398] | - |
Appears in Collections: | Aurora harvest 4 Ecology, Evolution and Landscape Science publications |
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