Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/119185
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Type: Journal article
Title: The role of depression pharmacogenetic decision support tools in shared decision making
Author: Arandjelovic, K.
Eyre, H.
Lenze, E.
Singh, A.
Berk, M.
Bousman, C.
Citation: Journal of Neural Transmission, 2019; 126(1):87-94
Publisher: Springer
Issue Date: 2019
ISSN: 0300-9564
1435-1463
Statement of
Responsibility: 
Katarina Arandjelovic, Harris A. Eyre, Eric Lenze, Ajeet B. Singh, Michael Berk, Chad Bousman
Abstract: Patients discontinue antidepressant medications due to lack of knowledge, unrealistic expectations, and/or unacceptable side effects. Shared decision making (SDM) invites patients to play an active role in their treatment and may indirectly improve outcomes through enhanced engagement in care, adherence to treatment, and positive expectancy of medication outcomes. We believe decisional aids, such as pharmacogenetic decision support tools (PDSTs), facilitate SDM in the clinical setting. PDSTs may likewise predict drug tolerance and efficacy, and therefore adherence and effectiveness on an individual-patient level. There are several important ethical considerations to be navigated when integrating PDSTs into clinical practice. The field requires greater empirical research to demonstrate clinical utility, and the mechanisms thereof, as well as exploration of the ethical use of these technologies.
Keywords: Adherence; Antidepressants; Decision support tool; Pharmacogenetics; Psychoeducation; Shared decision making; Therapeutic alliance
Rights: © Springer-Verlag GmbH Austria 2017
RMID: 0030085546
DOI: 10.1007/s00702-017-1806-8
Grant ID: http://purl.org/au-research/grants/nhmrc/1059660
Appears in Collections:Psychology publications

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