Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/119203
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Type: Journal article
Title: Desikan-Killiany-Tourville atlas compatible version of M-CRIB neonatal parcellated whole brain atlas: the M-CRIB 2.0
Author: Alexander, B.
Loh, W.Y.
Matthews, L.G.
Murray, A.L.
Adamson, C.
Beare, R.
Chen, J.
Kelly, C.E.
Anderson, P.J.
Doyle, L.W.
Spittle, A.J.
Cheong, J.L.
Seal, M.L.
Thompson, D.K.
Citation: Frontiers in Neuroscience, 2019; 13:34-1-34-9
Publisher: Frontiers Media
Issue Date: 2019
ISSN: 1662-4548
Statement of
Responsibility: 
Bonnie Alexander, Wai Yen Loh, Lillian G. Matthews, Andrea L. Murray, Chris Adamson, Richard Beare, Jian Chen, Claire E. Kelly, Peter J. Anderson, Lex W. Doyle, Alicia J. Spittle, Jeanie L. Y. Cheong, Marc L. Seal and Deanne K. Thompson
Abstract: Our recently published M-CRIB atlas comprises 100 neonatal brain regions including 68 compatible with the widely-used Desikan-Killiany adult cortical atlas. A successor to the Desikan-Killiany atlas is the Desikan-Killiany-Tourville atlas, in which some regions with unclear boundaries were removed, and many existing boundaries were revised to conform to clearer landmarks in sulcal fundi. Our first aim here was to modify cortical M-CRIB regions to comply with the Desikan-Killiany-Tourville protocol, in order to offer: (a) compatibility with this adult cortical atlas, (b) greater labeling accuracy due to clearer landmarks, and (c) optimisation of cortical regions for integration with surface-based infant parcellation pipelines. Secondly, we aimed to update subcortical regions in order to offer greater compatibility with subcortical segmentations produced in FreeSurfer. Data utilized were the T2-weighted MRI scans in our M-CRIB atlas, for 10 healthy neonates (post-menstrual age at MRI 40–43 weeks, four female), and corresponding parcellated images. Edits were performed on the parcellated images in volume space using ITK-SNAP. Cortical updates included deletion of frontal and temporal poles and ‘Banks STS,’ and modification of boundaries of many other regions. Changes to subcortical regions included the addition of ‘ventral diencephalon,’ and deletion of ‘subcortical matter’ labels. A detailed updated parcellation protocol was produced. The resulting whole-brain M-CRIB 2.0 atlas comprises 94 regions altogether. This atlas provides comparability with adult Desikan-Killiany-Tourville-labeled cortical data and FreeSurfer-labeed subcortical data, and is more readily adaptable for incorporation into surface-based neonatal parcellation pipelines. As such, it offers the ability to help facilitate a broad range of investigations into brain structure and function both at the neonatal time point and developmentally across the lifespan.
Keywords: Newborn; parcellation; segmentation; infant; ground truth; manual tracing
Rights: © 2019 Alexander, Loh,Matthews, Murray, Adamson, Beare, Chen, Kelly, Anderson, Doyle, Spittle, Cheong, Seal and Thompson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
RMID: 0030116795
DOI: 10.3389/fnins.2019.00034
Grant ID: http://purl.org/au-research/grants/nhmrc/1028822
http://purl.org/au-research/grants/nhmrc/546519
http://purl.org/au-research/grants/nhmrc/1060733
http://purl.org/au-research/grants/nhmrc/1081288
http://purl.org/au-research/grants/nhmrc/1053787
http://purl.org/au-research/grants/nhmrc/1053767
http://purl.org/au-research/grants/nhmrc/1012236
http://purl.org/au-research/grants/nhmrc/1108714
http://purl.org/au-research/grants/nhmrc/1085754
Appears in Collections:Dentistry publications

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