Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/119227
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dc.contributor.author | Newton, C. | - |
dc.contributor.author | Braconi, E. | - |
dc.contributor.author | Kuziola, J. | - |
dc.contributor.author | Wodrich, M. | - |
dc.contributor.author | Cramer, N. | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Angewandte Chemie International Edition, 2018; 57(34):11040-11044 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.issn | 1521-3773 | - |
dc.identifier.uri | http://hdl.handle.net/2440/119227 | - |
dc.description.abstract | Atropo-enantioselective C-H functionalization reactions are largely limited to the dynamic kinetic resolution of biaryl substrates through the introduction of steric bulk proximal to the axis of chirality. Reported herein is a highly atropo-enantioselective palladium(0)-catalyzed methodology that forges the axis of chirality during the C-H functionalization process, enabling the synthesis of axially chiral dibenzazepinones. Computational investigations support experimentally determined racemization barriers, while also indicating C-H functionalization proceeds by an enantio-determining CMD to yield configurationally stable eight-membered palladacycles. | - |
dc.description.statementofresponsibility | Christopher G. Newton, Elena Braconi, Jennifer Kuziola, Dr. Matthew D. Wodrich, Nicolai Cramer | - |
dc.language.iso | en | - |
dc.publisher | Wiley | - |
dc.rights | © 2018 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim | - |
dc.source.uri | http://dx.doi.org/10.1002/anie.201806527 | - |
dc.subject | C−H activation | - |
dc.subject | asymmetric catalysis | - |
dc.subject | atropisomer | - |
dc.subject | axial chirality | - |
dc.subject | palladium | - |
dc.title | Axially chiral dibenzazepinones by a palladium(0)-catalyzed atropo-enantioselective C−H arylation | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1002/anie.201806527 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Newton, C. [0000-0002-8962-5917] | - |
Appears in Collections: | Aurora harvest 8 Chemistry publications |
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