Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/119227
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dc.contributor.authorNewton, C.en
dc.contributor.authorBraconi, E.en
dc.contributor.authorKuziola, J.en
dc.contributor.authorWodrich, M.en
dc.contributor.authorCramer, N.en
dc.date.issued2018en
dc.identifier.citationAngewandte Chemie - International Edition, 2018; 57(34):11040-11044en
dc.identifier.issn1433-7851en
dc.identifier.issn1521-3773en
dc.identifier.urihttp://hdl.handle.net/2440/119227-
dc.description.abstractAtropo-enantioselective C-H functionalization reactions are largely limited to the dynamic kinetic resolution of biaryl substrates through the introduction of steric bulk proximal to the axis of chirality. Reported herein is a highly atropo-enantioselective palladium(0)-catalyzed methodology that forges the axis of chirality during the C-H functionalization process, enabling the synthesis of axially chiral dibenzazepinones. Computational investigations support experimentally determined racemization barriers, while also indicating C-H functionalization proceeds by an enantio-determining CMD to yield configurationally stable eight-membered palladacycles.en
dc.description.statementofresponsibilityChristopher G. Newton, Elena Braconi, Jennifer Kuziola, Dr. Matthew D. Wodrich, Nicolai Crameren
dc.language.isoenen
dc.publisherWileyen
dc.rights© 2018 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheimen
dc.subjectC−H activation; asymmetric catalysis; atropisomer; axial chirality; palladiumen
dc.titleAxially chiral dibenzazepinones by a palladium(0)-catalyzed atropo-enantioselective C−H arylationen
dc.typeJournal articleen
dc.identifier.rmid0030095284en
dc.identifier.doi10.1002/anie.201806527en
dc.identifier.pubid432997-
pubs.library.collectionChemistry publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidNewton, C. [0000-0002-8962-5917]en
Appears in Collections:Chemistry publications

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