Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/119288
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Type: Journal article
Title: Diffusion tensor imaging changes following mild, moderate and severe adult traumatic brain injury: a meta-analysis
Author: Wallace, E.
Mathias, J.
Ward, L.
Citation: Brain Imaging and Behavior, 2018; 12(6):1607-1621
Publisher: Springer Nature
Issue Date: 2018
ISSN: 1931-7557
1931-7565
Statement of
Responsibility: 
Erica J. Wallace, Jane L. Mathias, Lynn Ward
Abstract: Diffusion tensor imaging quantifies the asymmetry (fractional anisotropy; FA) and amount of water diffusion (mean diffusivity/apparent diffusion coefficient; MD/ADC) and has been used to assess white matter damage following traumatic brain injury (TBI). In healthy brains, diffusion is constrained by the organization of axons, resulting in high FA and low MD/ADC. Following a TBI, diffusion may be altered; however the exact nature of these changes has yet to be determined. A meta-analysis was therefore conducted to determine the location and extent of changes in DTI following adult TBI. The data from 44 studies that compared the FA and/or MD/ADC data from TBI and Control participants in different regions of interest (ROIs) were analyzed. The impact of injury severity, post-injury interval (acute: ≤ 1 week, subacute: 1 week-3 months, chronic: > 3 months), scanner details and acquisition parameters were investigated in subgroup analyses, with the findings indicating that mild TBI should be examined separately to that of moderate to severe injuries. Lower FA values were found in 88% of brain regions following mild TBI and 92% following moderate-severe TBI, compared to Controls. MD/ADC was higher in 95% and 100% of brain regions following mild and moderate-severe TBI, respectively. Moderate to severe TBI resulted in larger changes in FA and MD/ADC than mild TBI. Overall, changes to FA and MD/ADC were widespread, reflecting more symmetric and a higher amount of diffusion, indicative of white matter damage.
Keywords: Traumatic brain injury; diffusion tensor imaging; adults; outcomes; neuroimaging; meta-analysis
Rights: © Springer Science+Business Media, LLC, part of Springer Nature 2018
RMID: 0030081361
DOI: 10.1007/s11682-018-9823-2
Appears in Collections:Psychology publications

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