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Type: Journal article
Title: Evidence for hormonal control of heart regenerative capacity during endothermy acquisition
Author: Hirose, K.
Payumo, A.
Cutie, S.
Hoang, A.
Zhang, H.
Guyot, R.
Lunn, D.
Bigley, R.
Yu, H.
Wang, J.
Smith, M.
Gillett, E.
Muroy, S.
Schmid, T.
Wilson, E.
Field, K.
Reeder, D.
Maden, M.
Yartsev, M.
Wolfgang, M.
et al.
Citation: Science, 2019; 364(6436):184-188
Publisher: American Association for the Advancement of Science
Issue Date: 2019
ISSN: 0036-8075
Statement of
Kentaro Hirose, Alexander Y. Payumo, Stephen Cutie, Alison Hoang, Hao Zhang, Romain Guyot, Dominic Lunn, Rachel B. Bigley, Hongyao Yu, Jiajia Wang, Megan Smith, Ellen Gillett, Sandra E. Muroy, Tobias Schmid, Emily Wilson, Kenneth A. Field, DeeAnn M. Reeder, Malcom Maden, Michael M. Yartsev, Michael J. Wolfgang, Frank Grützner, Thomas S. Scanlan, Luke I. Szweda, Rochelle Buffenstein, Guang Hu, Frederic Flamant, Jeffrey E. Olgin, Guo N. Huang
Abstract: Tissue regenerative potential displays striking divergence across phylogeny and ontogeny, but the underlying mechanisms remain enigmatic. Loss of mammalian cardiac regenerative potential correlates with cardiomyocyte cell-cycle arrest and polyploidization as well as the development of postnatal endothermy. We reveal that diploid cardiomyocyte abundance across 41 species conforms to Kleiber’s law—the ¾-power law scaling of metabolism with bodyweight—and inversely correlates with standard metabolic rate, body temperature, and serum thyroxine level. Inactivation of thyroid hormone signaling reduces mouse cardiomyocyte polyploidization, delays cell-cycle exit, and retains cardiac regenerative potential in adults. Conversely, exogenous thyroid hormones inhibit zebrafish heart regeneration. Thus, our findings suggest that loss of heart regenerative capacity in adult mammals is triggered by increasing thyroid hormones and may be a trade-off for the acquisition of endothermy.
Keywords: Heart; thyroid hormone
Rights: Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works is an article distributed under the terms of the Science Journals Default License.
RMID: 0030110473
DOI: 10.1126/science.aar2038
Appears in Collections:Molecular and Biomedical Science publications

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