Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/120177
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dc.contributor.authorShorakae, S.en
dc.contributor.authorJona, E.en
dc.contributor.authorde Courten, B.en
dc.contributor.authorLambert, G.en
dc.contributor.authorLambert, E.en
dc.contributor.authorPhillips, S.en
dc.contributor.authorClarke, I.en
dc.contributor.authorTeede, H.en
dc.contributor.authorHenry, B.en
dc.date.issued2019en
dc.identifier.citationClinical Endocrinology, 2019; 90(3):425-432en
dc.identifier.issn0300-0664en
dc.identifier.issn1365-2265en
dc.identifier.urihttp://hdl.handle.net/2440/120177-
dc.description.abstractOBJECTIVE:Polycystic ovary syndrome (PCOS) is associated with increased obesity with a greater propensity to weight gain and a lack of sustainable lifestyle interventions. Altered brown adipose tissue (BAT) thermogenesis is a potential contributor to obesity in PCOS. BAT activity and modulation have not been studied in PCOS. This observational study explored BAT thermogenesis and its associations in women with and without PCOS. PARTICIPANTS AND METHODS:Cutaneous temperature was recorded from supraclavicular (indicator of BAT activity) and upper arm regions using dataloggers (SubCue, Calgary, Canada) in a cross-sectional substudy, nested within a randomized control trial, of community-recruited premenopausal women with (n = 47, Rotterdam diagnostic criteria) and without (n = 11) PCOS. RESULTS:Complete temperature data were available in 44 PCOS (mean age: 30.0 ± 6.2, mean BMI: 29.3 ± 5.5) and 11 non-PCOS (mean age: 33.0 ± 7.0, mean BMI: 25 ± 3) women. Women with PCOS had lower supraclavicular skin temperature compared to controls overall (33.9 ± 0.7 vs 34.5 ± 1, P < 0.05) and during sleep (34.5 ± 0.6 vs 35.2 ± 0.9, P < 0.001). In the PCOS group, supraclavicular skin temperature overall and over sleep and waking hours correlated inversely with testosterone (r = -0.41 P < 0.05, r = -0.485 P < 0.01 and r = -0.450 P < 0.01 respectively). Testosterone levels explained approximately 15%, 30% and 20% of the variability in supraclavicular skin temperature overall and over sleep and waking hours in women with PCOS, respectively. CONCLUSION:Women with PCOS have lower BAT activity compared to controls. BAT thermogenesis is negatively associated with androgen levels in PCOS.en
dc.description.statementofresponsibilitySoulmaz Shorakae, Eveline Jona, Barbora de Courten, Gavin W. Lambert, Elisabeth A. Lambert, Sarah E. Phillips, Iain J. Clarke, Helena J. Teede, Belinda A. Henryen
dc.language.isoenen
dc.publisherWiley Online Libraryen
dc.rights© 2018 John Wiley & Sons Ltd.en
dc.subjectbrown adipose tissue; hyperandrogenism; obesity; sympathetic nervous systemen
dc.titleBrown adipose tissue thermogenesis in polycystic ovary syndromeen
dc.typeJournal articleen
dc.identifier.rmid0030113622en
dc.identifier.doi10.1111/cen.13913en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1022793en
dc.identifier.pubid454346-
pubs.library.collectionPaediatrics publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidTeede, H. [0000-0001-7609-577X]en
Appears in Collections:Paediatrics publications

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