Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/120430
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Type: Journal article
Title: Two new spiro-heterocyclic γ-lactams from a marine-derived Aspergillus fumigatus strain CUGBMF170049
Other Titles: Two new spiro-heterocyclic gamma-lactams from a marine-derived Aspergillus fumigatus strain CUGBMF170049
Author: Xu, X.
Han, J.
Wang, Y.
Lin, R.
Yang, H.
Li, J.
Wei, S.
Polyak, S.
Song, F.
Citation: Marine Drugs, 2019; 17(5):289-1-289-8
Publisher: MDPI
Issue Date: 2019
ISSN: 1660-3397
1660-3397
Statement of
Responsibility: 
Xiuli Xu, Jiahui Han, Yanan Wang, Rui Lin, Haijin Yang, Jiangpeng Li, Shangzhu Wei, Steven W. Polyak, and Fuhang Song
Abstract: Two new spiro-heterocyclic γ-lactam derivatives, cephalimysins M (1) and N (2), were isolated from the fermentation cultures of the marine-derived fungus Aspergillus fumigatus CUGBMF17018. Two known analogues, pseurotin A (3) and FD-838 (4), as well as four previously reported helvolic acid derivatives, 16-O-propionyl-16-O-deacetylhelvolic acid (5), 6-O-propionyl-6-O-deacetylhelvolic acid (6), helvolic acid (7), and 1,2-dihydrohelvolic acid (8) were also identified. One-dimensional (1D), two-dimensional (2D) NMR, HRMS, and circular dichroism spectral analysis characterized the structures of the isolated compounds.
Keywords: Marine-derived Aspergillus fumigatus; spiro-heterocyclic γ-lactam; cephalimysins
Rights: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
RMID: 0030116323
DOI: 10.3390/md17050289
Grant ID: http://purl.org/au-research/grants/nhmrc/1147538
Appears in Collections:Molecular and Biomedical Science publications

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