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|Title:||Norbornene probes for the detection of cysteine sulfenic acid in cells|
|Citation:||ACS chemical biology, 2019; 14(4):594-598|
|Publisher:||American Chemical Society|
|Lisa J. Alcock, Bruno L. Oliveira, Michael J. Deery, Tara L. Pukala, Michael V. Perkins, Gonçalo J. L. Bernardes and Justin M. Chalker|
|Abstract:||Norbornene derivatives were validated as probes for cysteine sulfenic acid on proteins and in live cells. Trapping sulfenic acids with norbornene probes is highly selective and revealed a different reactivity profile than the traditional dimedone reagent. The norbornene probe also revealed a superior chemoselectivity when compared to a commonly used dimedone probe. Together, these results advance the study of cysteine oxidation in biological systems.|
|Rights:||© 2019 American Chemical Society|
|Appears in Collections:||Chemistry publications|
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