Adelaide Research & Scholarship
Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/120437
| Citations | ||
| Scopus | Web of Science® | Altmetric |
|---|---|---|
|
?
|
?
|
|
| Type: | Journal article |
| Title: | Norbornene probes for the detection of cysteine sulfenic acid in cells |
| Author: | Alcock, L.J. Oliveira, B.L. Deery, M.J. Pukala, T.L. Perkins, M.V. Bernardes, G.J.L. Chalker, J.M. |
| Citation: | ACS Chemical Biology, 2019; 14(4):594-598 |
| Publisher: | American Chemical Society |
| Issue Date: | 2019 |
| ISSN: | 1554-8929 1554-8937 |
| Statement of Responsibility: | Lisa J. Alcock, Bruno L. Oliveira, Michael J. Deery, Tara L. Pukala, Michael V. Perkins, Gonçalo J. L. Bernardes and Justin M. Chalker |
| Abstract: | Norbornene derivatives were validated as probes for cysteine sulfenic acid on proteins and in live cells. Trapping sulfenic acids with norbornene probes is highly selective and revealed a different reactivity profile than the traditional dimedone reagent. The norbornene probe also revealed a superior chemoselectivity when compared to a commonly used dimedone probe. Together, these results advance the study of cysteine oxidation in biological systems. |
| Keywords: | Norbornanes Cysteine Sulfenic Acids Molecular Probes Oxidation-Reduction |
| Rights: | © 2019 American Chemical Society |
| DOI: | 10.1021/acschembio.8b01104 |
| Grant ID: | http://purl.org/au-research/grants/arc/DE150101863 |
| Published version: | http://dx.doi.org/10.1021/acschembio.8b01104 |
| Appears in Collections: | Aurora harvest 8 Chemistry publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.