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Type: Journal article
Title: Norbornene probes for the detection of cysteine sulfenic acid in cells
Author: Alcock, L.J.
Oliveira, B.L.
Deery, M.J.
Pukala, T.L.
Perkins, M.V.
Bernardes, G.J.
Chalker, J.M.
Citation: ACS chemical biology, 2019; 14(4):594-598
Publisher: American Chemical Society
Issue Date: 2019
ISSN: 1554-8929
Statement of
Lisa J. Alcock, Bruno L. Oliveira, Michael J. Deery, Tara L. Pukala, Michael V. Perkins, Gonçalo J. L. Bernardes and Justin M. Chalker
Abstract: Norbornene derivatives were validated as probes for cysteine sulfenic acid on proteins and in live cells. Trapping sulfenic acids with norbornene probes is highly selective and revealed a different reactivity profile than the traditional dimedone reagent. The norbornene probe also revealed a superior chemoselectivity when compared to a commonly used dimedone probe. Together, these results advance the study of cysteine oxidation in biological systems.
Rights: © 2019 American Chemical Society
RMID: 0030111787
DOI: 10.1021/acschembio.8b01104
Grant ID:
Appears in Collections:Chemistry publications

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