Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/120979
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Type: | Journal article |
Title: | Peramivir and laninamivir susceptibility of circulating influenza A and B viruses |
Author: | Leang, S. Kwok, S. Sullivan, S. Maurer-Stroh, S. Kelso, A. Barr, I. Hurt, A. |
Citation: | Influenza and Other Respiratory Viruses, 2014; 8(2):135-139 |
Publisher: | Wiley |
Issue Date: | 2014 |
ISSN: | 1750-2640 1750-2659 |
Statement of Responsibility: | Sook-Kwan Leang, Simon Kwok, Sheena G. Sullivan, Sebastian Maurer-Stroh, Anne Kelso, Ian G. Barr, Aeron C. Hurt |
Abstract: | Influenza viruses collected from regions of Asia, Africa and Oceania between 2009 and 2012 were tested for their susceptibility to two new neuraminidase inhibitors, peramivir and laninamivir. All viruses tested had normal laninamivir inhibition. However, 3·2% (19/599) of A(H1N1)pdm09 viruses had highly reduced peramivir inhibition (due to H275Y NA mutation) and <1% (6/1238) of influenza B viruses had reduced or highly reduced peramivir inhibition, with single occurrence of variants containing I221T, A245T, K360E, A395E, D432G and a combined G145R+Y142H mutation. These data demonstrate that despite an increase in H275Y variants in 2011, there was no marked change in the frequency of peramivir- or laninamivir-resistant variants following the market release of the drugs in Japan in 2010. |
Keywords: | Antiviral susceptibility; laninamivir; neuraminidase inhibitors; peramivir |
Rights: | © 2013 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
DOI: | 10.1111/irv.12187 |
Grant ID: | NHMRC |
Published version: | http://dx.doi.org/10.1111/irv.12187 |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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hdl_120979.pdf | Published Version | 202.98 kB | Adobe PDF | View/Open |
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