Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/121476
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Type: Journal article
Title: Nanoscale study of cartilage surfaces using atomic force microscopy
Author: Wang, M.
Peng, Z.
Watson, J.A.
Watson, G.S.
Yin, L.
Citation: Proceedings of the Institution of Mechanical Engineers Part H: Journal of Engineering in Medicine, 2012; 226(12):899-910
Publisher: SAGE Publications
Issue Date: 2012
ISSN: 0954-4119
2041-3033
Statement of
Responsibility: 
Meiling Wang, Zhongxiao Peng, Jolanta A Watson, Gregory S Watson and Ling Yin
Abstract: Articulating cartilage wear plays an important role in cartilage degeneration and osteoarthritis (OA) progression. This study investigated the changes of mechanical properties and surface roughness of sheep cartilages with wear progression at a nanometre scale. Young sheep's rear legs were subjected to a series of wear tests to generate worn cartilage samples to simulate the OA progression. Atomic force microscopy (AFM) was used to determine the effective indentation modulus and to measure the surface morphology of moist cartilage surfaces. The study has found that the mean effective indentation modulus values of worn cartilages were lower than that of healthy cartilage as the control sample. A medium-to-strong correlation between the effective indentation modulus values and the OA grades has been found. The relation between surface topography and effective indentation modulus values of the cartilage surfaces with OA progression was weakly correlated. The method established in this study can be implemented to investigate the effective indentation modulus values of clinical osteoarthritic cartilages and to assist in the understanding and assessment of OA.
Keywords: Effective indentation modulus; cartilage surface; surface morphology; wear; atomic force microscopy
Rights: © IMechE 2012 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav
DOI: 10.1177/0954411912460482
Grant ID: http://purl.org/au-research/grants/arc/DP1093975
Published version: http://dx.doi.org/10.1177/0954411912460482
Appears in Collections:Aurora harvest 8
Mechanical Engineering publications

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