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Type: Journal article
Title: Bioinspired core-shell nanoparticles for hydrophobic drug delivery
Author: Yang, G.
Liu, Y.
Wang, H.
Wilson, R.
Hui, Y.
Yu, L.
Wibowo, D.
Zhang, C.
Whittaker, A.
Middelberg, A.
Zhao, C.
Citation: Angewandte Chemie - International Edition, 2019; 58(40):14357-14364
Publisher: Wiley
Issue Date: 2019
ISSN: 1433-7851
Statement of
Guangze Yang, Yun Liu, Haofei Wang, Russell Wilson, Yue Hui ... Anton P. J. Middelberg ... et al.
Abstract: A large range of nanoparticles have been developed to encapsulate hydrophobic drugs. However, drug loading is usually less than 10 % or even 1 %. Now, core-shell nanoparticles are fabricated having exceptionally high drug loading up to 65 % (drug weight/the total weight of drug-loaded nanoparticles) and high encapsulation efficiencies (>99 %) based on modular biomolecule templating. Bifunctional amphiphilic peptides are designed to not only stabilize hydrophobic drug nanoparticles but also induce biosilicification at the nanodrug particle surface thus forming drug-core silica-shell nanocomposites. This platform technology is highly versatile for encapsulating various hydrophobic cargos. Furthermore, the high drug loading nanoparticles lead to better in vitro cytotoxic effects and in vivo suppression of tumor growth, highlighting the significance of using high drug-loading nanoparticles.
Keywords: biomimetic synthesis; cancer; drug delivery; nanoparticles; peptides
Rights: © 2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim
RMID: 0030134483
DOI: 10.1002/anie.201908357
Grant ID:
Appears in Collections:Chemistry publications

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