Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Bioinspired core-shell nanoparticles for hydrophobic drug delivery|
|Citation:||Angewandte Chemie - International Edition, 2019; 58(40):14357-14364|
|Guangze Yang, Yun Liu, Haofei Wang, Russell Wilson, Yue Hui ... Anton P. J. Middelberg ... et al.|
|Abstract:||A large range of nanoparticles have been developed to encapsulate hydrophobic drugs. However, drug loading is usually less than 10 % or even 1 %. Now, core-shell nanoparticles are fabricated having exceptionally high drug loading up to 65 % (drug weight/the total weight of drug-loaded nanoparticles) and high encapsulation efficiencies (>99 %) based on modular biomolecule templating. Bifunctional amphiphilic peptides are designed to not only stabilize hydrophobic drug nanoparticles but also induce biosilicification at the nanodrug particle surface thus forming drug-core silica-shell nanocomposites. This platform technology is highly versatile for encapsulating various hydrophobic cargos. Furthermore, the high drug loading nanoparticles lead to better in vitro cytotoxic effects and in vivo suppression of tumor growth, highlighting the significance of using high drug-loading nanoparticles.|
|Keywords:||biomimetic synthesis; cancer; drug delivery; nanoparticles; peptides|
|Rights:||© 2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim|
|Appears in Collections:||Chemistry publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.