Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/121487
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Common genetic architecture and environmental risk factors underpin the anxiety-disordered eating relationship: findings from an adolescent twin cohort
Author: Fairweather-Schmidt, A.
Wade, T.
Citation: International Journal of Eating Disorders, 2020; 53(1):52-60
Publisher: Wiley
Issue Date: 2020
ISSN: 0276-3478
1098-108X
Statement of
Responsibility: 
A. Kate Fairweather-Schmidt, Tracey D. Wade
Abstract: OBJECTIVE:Despite established comorbidity between anxiety and disordered eating (DE), and a plethora of research using various methodologies to examine this overlap, use of twin modeling to expose whether a shared genetic liability underpins these conditions remains rare. METHOD:Data from a longitudinal sample of female twins were selected: measures of risk for DE from Wave 1 (N = 699, 351 pairs, aged 12-15 years), and the Eating Disorder Examination (EDE) and Children's Anxiety Sensitivity Index (CASI) from Wave 2 (N = 669, 338 pairs, aged 16-19 years). At this time, they also completed Children's Anxiety Sensitivity Index (CASI). Bivariate Cholesky decomposition models adjusting for age and body mass index centile investigated the covariance structure between the CASI and EDE. RESULTS:Modeling both genetic and nonshared environmental influences parsimoniously fit these data. All paths were significant. Additive genetic influences were notable for CASI and EDE phenotypes; 14% of the heritable variance was contributed by CASI to the expression of EDE. There was also a smaller but significant contribution of nonshared environmental influences. A multinomial logistic regression indicated body dissatisfaction (RRR = 1.53; 95% CI = 1.07-2.18) differentiated groups with highest EDE scores from the highest CASI scores. DISCUSSION:Shared genetic and environmental influences appear to underpin the relationship, and potentially the observed comorbidity, between anxiety sensitivity and DE. The age of onset is typically earlier for anxiety than DE, suggesting a significant opportunity for early intervention work to reduce the likelihood of subsequent development of DE.
Keywords: adolescents; anxiety sensitivity; disordered eating; environmental; genetic; twins
Rights: © 2019 Wiley Periodicals, Inc.
RMID: 0030133452
DOI: 10.1002/eat.23155
Grant ID: http://purl.org/au-research/grants/nhmrc/324715
http://purl.org/au-research/grants/nhmrc/480420
Appears in Collections:Genetics publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.