Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/121508
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Type: Journal article
Title: Critical limb ischemia: current and novel therapeutic strategies
Author: Hassanshahi, M.
Khabbazi, S.
Peymanfar, Y.
Hassanshahi, A.
Hosseini-Khah, Z.
Su, Y.
Xian, C.
Citation: Journal of Cellular Physiology, 2019; 234(9):14445-14459
Publisher: Wiley
Issue Date: 2019
ISSN: 0021-9541
1097-4652
Statement of
Responsibility: 
Mohammadhossein Hassanshahi, Samira Khabbazi, Yaser Peymanfar, Alireza Hassanshahi, Zahra Hosseini‐Khah, Yu‐Wen Su, Cory J. Xian
Abstract: Critical limb ischemia (CLI) is the advanced stage of peripheral artery disease spectrum and is defined by limb pain or impending limb loss because of compromised blood flow to the affected extremity. Current conventional therapies for CLI include amputation, bypass surgery, endovascular therapy, and pharmacological approaches. Although these conventional therapeutic strategies still remain as the mainstay of treatments for CLI, novel and promising therapeutic approaches such as proangiogenic gene/protein therapies and stem cell-based therapies have emerged to overcome, at least partially, the limitations and disadvantages of current conventional therapeutic approaches. Such novel CLI treatment options may become even more effective when other complementary approaches such as utilizing proper bioscaffolds are used to increase the survival and engraftment of delivered genes and stem cells. Therefore, herein, we address the benefits and disadvantages of current therapeutic strategies for CLI treatment and summarize the novel and promising therapeutic approaches for CLI treatment. Our analyses also suggest that these novel CLI therapeutic strategies show considerable advantages to be used when current conventional methods have failed for CLI treatment.
Keywords: angiogenesis; bio-scaffolds; critical limb ischemia; stem cell therapy
Rights: © 2019 Wiley Periodicals, Inc.
RMID: 0030106582
DOI: 10.1002/jcp.28141
Grant ID: http://purl.org/au-research/grants/nhmrc/1042105
http://purl.org/au-research/grants/nhmrc/508046
http://purl.org/au-research/grants/nhmrc/508047
Appears in Collections:Biochemistry publications

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