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Type: Journal article
Title: Erectile dysfunction is independently associated with apnea-hypopnea index and oxygen desaturation index in elderly, but not younger, community-dwelling men
Author: Martin, S.
Appleton, S.
Adams, R.
Taylor, A.
Vincent, A.
Brook, N.
Catcheside, P.
Vakulin, A.
McEvoy, R.
Antic, N.
Wittert, G.
Citation: Sleep Health, 2017; 3(4):250-256
Publisher: Elsevier
Issue Date: 2017
ISSN: 2352-7218
Statement of
Sean A. Martin, Sarah L. Appleton, Robert J. Adams, AnneW. Taylor, Andrew Vincent, Nicholas R. Brook, Peter G. Catcheside, Andrew Vakulin, Douglas McEvoy, Nick A. Antic, Gary A. Wittert
Abstract: To examine the association between obstructive sleep apnea (OSA) and other sleep indices using polysomnography (PSG) data and erectile dysfunction (ED) in a representative cohort of men.Cross-sectional.Community-based.Aged 40+ years (n=734; mean age [SD], 60.8 [10.9]).Men with no prior OSA diagnosis who underwent in-home PSG (Embletta X100; 2010-11) and ED assessment (Global Impotence Rating) were selected. Un-adjusted and multi-adjusted regression models of ED were fitted against PSG measures, along with qualifying sociodemographic, lifestyle, and health-related covariates. Mediation effects were examined using the Baron-Kenny method.Of the men examined, 24.7% (n=181) had ED, most notably in men older than 65years (cf. men 35-49 and 50-64years; P<.001). There was no significant association between ED and any of the PSG measures for allaged men. Given an observed ageinteraction within OSA categories (P=.005), analyses were repeated in age-stratified samples (<65 years; 65+ years). In men younger than 65years, only severe OSA was found to have an association with ED (2.01; 1.13-4.69) in unadjusted models. For men aged 65+ years, an independent association with ED was found for apnea-hyponea index (AHI; 1.55;1.02-2.36), moderate (AHI:10.0-19.9; 1.79;1.18-2.43), and severe (AHI:20.0+; 4.84;2.56-9.93) OSA, and oxygen desaturation index (ODI; both continuous [1.48;1.03-1.99] and >16 seconds [2.79;1.23-6.32]). The effect of AHI on ED was shown to be primarily mediated through ODI (63.4%, Sobel P value=.29).In younger, community-based men, there appeared no independent relationship between objective measures of sleep and ED. However, there appears a strong, independent relationship between OSA, ODI, and ED in men 65 years and older.
Keywords: Humans; Sleep Apnea, Obstructive; Oxygen; Polysomnography; Severity of Illness Index; Risk Factors; Cohort Studies; Cross-Sectional Studies; Age Factors; Middle Aged; Male; Erectile Dysfunction; Independent Living
Rights: © 2017 National Sleep Foundation. Published by Elsevier Inc. All rights reserved.
RMID: 0030071507
DOI: 10.1016/j.sleh.2017.04.006
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Appears in Collections:Medicine publications

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