Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/122310
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dc.contributor.advisorAbell, Andrew-
dc.contributor.advisorGeorge, Jonathan-
dc.contributor.authorLee, Kwang Jun-
dc.date.issued2019-
dc.identifier.urihttp://hdl.handle.net/2440/122310-
dc.description.abstractPARTIAL ABSTRACT: Biotin is an essential vitamin that is required for growth and pathogenicity of bacteria. Biotin protein ligase (BPL) catalyses the ordered reaction of biotin and ATP to give biotinyl-5̕´-MP, which then activates a number of biotin dependent enzymes that are critical to cell survival. Dethiobiotin synthase (DTBS) is the sole enzyme responsible for catalysing a key step in biotin biosynthesis, namely the carboxylation of 7,8-diaminopelargonic acid (DAPA), closing the ureido ring to form dethiobiotin in a reaction requiring a nucleotide triphosphate. Research undertaken in this thesis highlights strategies to selectively inhibit Staphylococcus aureus biotin protein ligase (SaBPL) using 1,2,3-triazole and sulfonamide isosteres to replace the phosphoroanhydride linker found in biotinyl-5´-AMP. In addition, this thesis discusses the design and development of inhibitors targeting Mycobacterium tuberculosis dethiobiotin synthase (MtbDTBS).en
dc.language.isoenen
dc.subjectAntibioticen
dc.subjectbiotin protein ligaseen
dc.subjectdethiobiotin synthaseen
dc.subjectenzyme inhibitoren
dc.titleDevelopment of New Antibiotics Based on Biotin Biologyen
dc.typeThesisen
dc.contributor.schoolSchool of Physical Sciencesen
dc.provenanceThis thesis is currently under Embargo and not availableen
dc.description.dissertationThesis (Ph.D.) -- University of Adelaide, School of Physical Sciences, 2019en
Appears in Collections:Research Theses

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