Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/122812
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Type: Journal article
Title: Endocrine characteristics, body mass index and metabolic syndrome in women with polycystic ovary syndrome
Author: Li, J.
Wu, Q.
Wang, C.
Wang, R.
Ng, E.
Liu, J.
Mol, B.
Wu, X.
Li, W.
Citation: Reproductive BioMedicine Online, 2019; 39(5):868-876
Publisher: Elsevier
Issue Date: 2019
ISSN: 1472-6483
1472-6491
Statement of
Responsibility: 
Jian Li, Qi Wu, Chi Chiu Wang, Rui Wang, Ernest H.Y. Ng, Jian-Ping Liu, Ben Willem J. Mol, Xiao-Ke Wu, Wen-Tao Li, PCOSAct Study Group
Abstract: Research Question: The study aimed to evaluate the associations of endocrine and ultrasound characteristics with metabolic syndrome in women with polycystic ovary syndrome (PCOS), and whether these associations were modified by body mass index (BMI). Design: The study was a secondary analysis of baseline data from a randomized controlled trial of induction of ovulation in women with PCOS. Results: Among 947 Chinese women with PCOS, 153 (16.2%) were diagnosed with metabolic syndrome. The prevalence of metabolic syndrome in women with normal (<24 kg/m2) and high (≥24 kg/m2) BMI was 3.6% and 30.5%, respectively. In all women, a high free androgen index (FAI ≥5%) was positively associated with metabolic syndrome (adjusted odds ratio [OR] 2.06, 95% confidence interval [CI] 1.11-3.82). High FAI was positively associated with metabolic syndrome among women with high BMI (adjusted OR 3.37, 95% CI 1.78-6.37), but the association was not significant in women with normal BMI (adjusted OR 1.27, 95% CI 0.34-4.70). The presence of polycystic ovary morphology was negatively associated with metabolic syndrome (adjusted OR 0.52, 95% CI 0.26-1.03) in all women (normal BMI adjusted OR 0.42, 95% CI 0.11-1.67; high BMI adjusted OR 0.54, 95% CI 0.23-1.28). LH, sex hormone-binding globulin (SHBG) and anti-Müllerian hormone (AMH) were negatively associated with metabolic syndrome. The associations of FAI, SHBG and AMH in relation to metabolic syndrome were significantly modified by BMI. Conclusion(s): The associations of endocrine characteristic with metabolic syndrome were modified by BMI in women with PCOS. Women with PCOS and normal BMI did not have an increased risk of metabolic syndrome.
Keywords: Body mass index; metabolic syndrome; polycystic ovary syndrome
Rights: © 2019 Published by Elsevier Ltd on behalf of Reproductive Healthcare Ltd.
RMID: 0030133419
DOI: 10.1016/j.rbmo.2019.06.014
Grant ID: http://purl.org/au-research/grants/nhmrc/1078444
http://purl.org/au-research/grants/nhmrc/GNT1082548
Appears in Collections:Obstetrics and Gynaecology publications

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