Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/122812
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dc.contributor.authorLi, J.en
dc.contributor.authorWu, Q.en
dc.contributor.authorWang, C.en
dc.contributor.authorWang, R.en
dc.contributor.authorNg, E.en
dc.contributor.authorLiu, J.en
dc.contributor.authorMol, B.en
dc.contributor.authorWu, X.en
dc.contributor.authorLi, W.en
dc.date.issued2019en
dc.identifier.citationReproductive BioMedicine Online, 2019; 39(5):868-876en
dc.identifier.issn1472-6483en
dc.identifier.issn1472-6491en
dc.identifier.urihttp://hdl.handle.net/2440/122812-
dc.description.abstractResearch Question: The study aimed to evaluate the associations of endocrine and ultrasound characteristics with metabolic syndrome in women with polycystic ovary syndrome (PCOS), and whether these associations were modified by body mass index (BMI). Design: The study was a secondary analysis of baseline data from a randomized controlled trial of induction of ovulation in women with PCOS. Results: Among 947 Chinese women with PCOS, 153 (16.2%) were diagnosed with metabolic syndrome. The prevalence of metabolic syndrome in women with normal (<24 kg/m2) and high (≥24 kg/m2) BMI was 3.6% and 30.5%, respectively. In all women, a high free androgen index (FAI ≥5%) was positively associated with metabolic syndrome (adjusted odds ratio [OR] 2.06, 95% confidence interval [CI] 1.11-3.82). High FAI was positively associated with metabolic syndrome among women with high BMI (adjusted OR 3.37, 95% CI 1.78-6.37), but the association was not significant in women with normal BMI (adjusted OR 1.27, 95% CI 0.34-4.70). The presence of polycystic ovary morphology was negatively associated with metabolic syndrome (adjusted OR 0.52, 95% CI 0.26-1.03) in all women (normal BMI adjusted OR 0.42, 95% CI 0.11-1.67; high BMI adjusted OR 0.54, 95% CI 0.23-1.28). LH, sex hormone-binding globulin (SHBG) and anti-Müllerian hormone (AMH) were negatively associated with metabolic syndrome. The associations of FAI, SHBG and AMH in relation to metabolic syndrome were significantly modified by BMI. Conclusion(s): The associations of endocrine characteristic with metabolic syndrome were modified by BMI in women with PCOS. Women with PCOS and normal BMI did not have an increased risk of metabolic syndrome.en
dc.description.statementofresponsibilityJian Li, Qi Wu, Chi Chiu Wang, Rui Wang, Ernest H.Y. Ng, Jian-Ping Liu, Ben Willem J. Mol, Xiao-Ke Wu, Wen-Tao Li, PCOSAct Study Groupen
dc.language.isoenen
dc.publisherElsevieren
dc.rights© 2019 Published by Elsevier Ltd on behalf of Reproductive Healthcare Ltd.en
dc.subjectBody mass index; metabolic syndrome; polycystic ovary syndromeen
dc.titleEndocrine characteristics, body mass index and metabolic syndrome in women with polycystic ovary syndromeen
dc.typeJournal articleen
dc.identifier.rmid0030133419en
dc.identifier.doi10.1016/j.rbmo.2019.06.014en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1078444en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/GNT1082548en
dc.identifier.pubid493521-
pubs.library.collectionObstetrics and Gynaecology publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidWang, R. [0000-0002-6622-8134]en
dc.identifier.orcidMol, B. [0000-0001-8337-550X]en
Appears in Collections:Obstetrics and Gynaecology publications

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