Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/124131
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Type: Journal article
Title: NAD⁺ repletion rescues female fertility during reproductive aging
Other Titles: NAD(+) repletion rescues female fertility during reproductive aging
Author: Bertoldo, M.
Listijono, D.
Ho, W.
Riepsamen, A.
Goss, D.
Richani, D.
Jin, X.
Mahbub, S.
Campbell, J.
Habibalahi, A.
Loh, W.
Youngson, N.
Maniam, J.
Wong, A.
Selesniemi, K.
Bustamante, S.
Li, C.
Zhao, Y.
Marinova, M.
Kim, L.
et al.
Citation: Cell Reports, 2020; 30(6):1670-1681.e7
Publisher: Elsevier
Issue Date: 2020
ISSN: 2211-1247
2211-1247
Statement of
Responsibility: 
Yoshiaki Tanaka, Bilal Cakir, Yangfei Xiang, Gareth J. Sullivan, In-Hyun Park
Abstract: Reproductive aging in female mammals is an irreversible process associated with declining oocyte quality, which is the rate-limiting factor to fertility. Here, we show that this loss of oocyte quality with age accompanies declining levels of the prominent metabolic cofactor nicotinamide adenine dinucleotide (NAD+). Treatment with the NAD+ metabolic precursor nicotinamide mononucleotide (NMN) rejuvenates oocyte quality in aged animals, leading to restoration in fertility, and this can be recapitulated by transgenic overexpression of the NAD+-dependent deacylase SIRT2, though deletion of this enzyme does not impair oocyte quality. These benefits of NMN extend to the developing embryo, where supplementation reverses the adverse effect of maternal age on developmental milestones. These findings suggest that late-life restoration of NAD+ levels represents an opportunity to rescue female reproductive function in mammals.
Keywords: Embryo development
Description: Published:February 11, 2020
Rights: © 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
RMID: 1000014809
DOI: 10.1016/j.celrep.2020.01.058
Grant ID: http://purl.org/au-research/grants/nhmrc/1103689
http://purl.org/au-research/grants/nhmrc/122484
http://purl.org/au-research/grants/nhmrc/113976
http://purl.org/au-research/grants/nhmrc/1044295
http://purl.org/au-research/grants/nhmrc/1066172
http://purl.org/au-research/grants/nhmrc/1127821
http://purl.org/au-research/grants/arc/CE140100003
http://purl.org/au-research/grants/arc/DP170101863
Appears in Collections:Public Health publications

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