Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/124131
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Type: | Journal article |
Title: | NAD⁺ repletion rescues female fertility during reproductive aging |
Other Titles: | NAD(+) repletion rescues female fertility during reproductive aging |
Author: | Bertoldo, M.J. Listijono, D.R. Ho, W.H.J. Riepsamen, A.H. Goss, D.M. Richani, D. Jin, X.L. Mahbub, S. Campbell, J.M. Habibalahi, A. Loh, W.G.N. Youngson, N.A. Maniam, J. Wong, A.S.A. Selesniemi, K. Bustamante, S. Li, C. Zhao, Y. Marinova, M.B. Kim, L.J. et al. |
Citation: | Cell Reports, 2020; 30(6):1670-1681.e7 |
Publisher: | Elsevier |
Issue Date: | 2020 |
ISSN: | 2211-1247 2211-1247 |
Statement of Responsibility: | Yoshiaki Tanaka, Bilal Cakir, Yangfei Xiang, Gareth J. Sullivan, In-Hyun Park |
Abstract: | Reproductive aging in female mammals is an irreversible process associated with declining oocyte quality, which is the rate-limiting factor to fertility. Here, we show that this loss of oocyte quality with age accompanies declining levels of the prominent metabolic cofactor nicotinamide adenine dinucleotide (NAD+). Treatment with the NAD+ metabolic precursor nicotinamide mononucleotide (NMN) rejuvenates oocyte quality in aged animals, leading to restoration in fertility, and this can be recapitulated by transgenic overexpression of the NAD+-dependent deacylase SIRT2, though deletion of this enzyme does not impair oocyte quality. These benefits of NMN extend to the developing embryo, where supplementation reverses the adverse effect of maternal age on developmental milestones. These findings suggest that late-life restoration of NAD+ levels represents an opportunity to rescue female reproductive function in mammals. |
Keywords: | Embryo development |
Description: | Published:February 11, 2020 |
Rights: | © 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
DOI: | 10.1016/j.celrep.2020.01.058 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1103689 http://purl.org/au-research/grants/nhmrc/122484 http://purl.org/au-research/grants/nhmrc/113976 http://purl.org/au-research/grants/nhmrc/1044295 http://purl.org/au-research/grants/nhmrc/1066172 http://purl.org/au-research/grants/nhmrc/1127821 http://purl.org/au-research/grants/arc/CE140100003 http://purl.org/au-research/grants/arc/DP170101863 |
Published version: | http://dx.doi.org/10.1016/j.celrep.2020.01.058 |
Appears in Collections: | Aurora harvest 8 Public Health publications |
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hdl_124131.pdf | Published version | 4.02 MB | Adobe PDF | View/Open |
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