Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/124212
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Type: | Journal article |
Title: | GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI |
Author: | Alves, A.C. De Silva, N.M.G. Karhunen, V. Sovio, U. Das, S. Rob Taal, H. Warrington, N.M. Lewin, A.M. Kaakinen, M. Cousminer, D.L. Thiering, E. Timpson, N.J. Bond, T.A. Lowry, E. Brown, C.D. Estivill, X. Lindi, V. Bradfield, J.P. Geller, F. Speed, D. et al. |
Citation: | Science Advances, 2019; 5(9):1-17 |
Publisher: | American Association for the Advancement of Science |
Issue Date: | 2019 |
ISSN: | 2375-2548 2375-2548 |
Statement of Responsibility: | Alexessander Couto Alves ... Debbie A. Lawlor ... Lyle J. Palmer ... et al. ... [The Early Growth Genetics (EGG) Consortium] |
Abstract: | Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies. |
Keywords: | BIOS Consortium Early Growth Genetics (EGG) Consortium Humans Genetic Predisposition to Disease Intracellular Signaling Peptides and Proteins Adaptor Proteins, Signal Transducing Body Mass Index Longitudinal Studies Genomics Quantitative Trait, Heritable Polymorphism, Single Nucleotide Quantitative Trait Loci Adult Child Infant Female Male Receptors, Leptin Genome-Wide Association Study Genetic Association Studies Growth Charts Pharmacogenomic Variants |
Rights: | Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
DOI: | 10.1126/sciadv.aaw3095 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/403981 http://purl.org/au-research/grants/nhmrc/003209 |
Published version: | http://dx.doi.org/10.1126/sciadv.aaw3095 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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hdl_124212.pdf | Published version | 1.83 MB | Adobe PDF | View/Open |
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