Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/127163
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Type: Journal article
Title: Testicular volume and clinical correlates of hypothalamic-pituitary-testicular function: A cross-sectional study in obese men
Author: Tang Fui, M.N.
Hoermann, R.
Wittert, G.
Grossmann, M.
Citation: Asian Journal of Andrology, 2019; 22(4):1-6
Publisher: Medknow Publications
Issue Date: 2019
ISSN: 1008-682X
1745-7262
Statement of
Responsibility: 
Mark Ng Tang Fui, Rudolf Hoermann, Gary Wittert, Mathis Grossmann
Abstract: The aim of this study was to determine whether testicular volume is correlated with clinical and biochemical markers of hypothalamic-pituitary-testicular (HPT) axis function. This was a cross-sectional substudy of a larger randomized controlled trial including obese men, body mass index (BMI) ≥30 kg m-2, with a total testosterone level <12 nmol l-1. Testicular volume was measured by orchidometer, testosterone by liquid chromatography/tandem mass spectrometry, and body composition by dual-energy X-ray absorptiometry. Men completed the Aging Males' Symptoms (AMS) score, International Index of Erectile Function-5 (IIEF-5), physical function, and handgrip dynamometer testing. Eighty-nine men participated with a median (interquartile range [IQR]) age of 53.1 (47.6, 59.2) years, BMI of 37.0 (34.6, 40.5) kg m-2, and a total testosterone of 7.0 (6.1, 7.9) nmol l-1. Median testicular volume was 18 (IQR: 10, 20) ml. Testicular volume was negatively correlated with BMI (τ = -0.1952, P = 0.010) and total fat mass (τ = -0.2115, P = 0.005) independent of age and testosterone. When BMI, testosterone, sex hormone-binding globulin (SHBG), and luteinizing hormone (LH) were present in a multivariable model, only BMI (-0.38 ml change in testicular volume per 1 kg m-2BMI; 95% CI: -0.74, -0.02; P = 0.04) and LH (-0.92 ml change in testicular volume per 1 IU l-1 LH; 95% CI: -1.75, -0.095; P = 0.03) remained independent significant predictors of testicular volume. Testicular volume was positively correlated with IIEF-5 (τ = 0.2092, P = 0.021), but not related to handgrip strength, physical function tests, or AMS. In obese men, testicular volume is inversely and independently associated with measures of adiposity, but not with most clinical or biochemical markers of HPT axis action. From a clinical perspective, this suggests that obesity might compromise the reliability of reduced testicular volume as a sign of androgen deficiency in men.
Keywords: gonadal axis; hypothalamic–; pituitary–; testicular volume; testosterone
Rights: ©The Author(s)(2019). This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
RMID: 1000000457
DOI: 10.4103/aja.aja_96_19
Grant ID: http://purl.org/au-research/grants/nhmrc/1024139
Appears in Collections:Obstetrics and Gynaecology publications

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