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Type: Journal article
Title: Isolation and biomimetic oxidation of prenylbruceol A, an anticipated meroterpenoid natural product from philotheca myoporoides
Author: Day, A.J.
George, J.H.
Citation: Journal of Natural Products, 2020; 83(7):2305-2309
Publisher: ACS Publications
Issue Date: 2020
ISSN: 0163-3864
Statement of
Aaron J. Day and Jonathan H. George
Abstract: Reinvestigation of the coumarin meroterpenoids of Philotheca myoporoides using pressurized hot water extraction (PHWE) procedures led to the isolation of prenylbruceol A, a proposed biosynthetic precursor of seven previously reported bruceol derivatives, prenylbruceols B-H. Protobruceol-I, ostruthin, dipetalactone, and a new dihydrocoumarin natural product were isolated alongside prenylbruceol A. A biomimetic singlet oxygen ene reaction of prenylbruceol A allowed the semisynthesis of prenylbruceols B, C, and D.
Keywords: Rutaceae
Biological Products
Spectrum Analysis
Molecular Structure
Rights: © 2020 American Chemical Society and American Society of Pharmacognosy
DOI: 10.1021/acs.jnatprod.0c00348
Grant ID:
Appears in Collections:Aurora harvest 4
Pharmacology publications

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