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https://hdl.handle.net/2440/129772
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Type: | Journal article |
Title: | Hospitalisations for non-fatal overdose among people with a history of opioid dependence in New South Wales, Australia, 2001-2018: findings from the OATS retrospective cohort study |
Author: | Jones, N.R. Hickman, M. Larney, S. Nielsen, S. Ali, R. Murphy, T. Dobbins, T. Fiellin, D.A. Degenhardt, L. |
Citation: | Drug and Alcohol Dependence, 2021; 218:108354-1-108354-10 |
Publisher: | Elsevier |
Issue Date: | 2021 |
ISSN: | 0376-8716 1879-0046 |
Statement of Responsibility: | Nicola R. Jones, Matthew Hickman, Sarah Larney, Suzanne Nielsen, Robert Ali, Thomas Murphy ... et al. |
Abstract: | BACKGROUND:To examine, among a cohort of opioid dependent people with a history of opioid agonist treatment (OAT), the frequency and incidence rates of non-fatal overdose (NFOD) hospital separations over time, by age and sex. METHODS:Retrospective cohort study of people with a history of OAT using state-wide linked New South Wales (NSW) data. The incidence of NFOD hospital separations involving an opioid, sedative, stimulant or alcohol was defined according to the singular or combination of poisoning/toxic effect using ICD-10-AM codes. Crude incidence rates were calculated by gender, age group and calendar year. RESULTS:There were 31.8 (31.3-32.3) NFOD per 1,000 person-years (PY). Opioid NFOD incidence was higher in women than men: incidence rate ratio (IRR) 1.11 per 1,000PY; 95 %CI: [1.06-1.17]; women had higher sedative NFOD rates than men, IRR 1.27 per 1,000PY [1.21-1.34]. Participants ≤25 years, 26-30yrs, and 31-35yrs had higher incidence of opioid NFOD compared to 46+yrs, with IRRs of: 1.45 per 1,000PY; [1.32-1.59]; 1.20 per 1,000PY; [1.11-1.30] and 1.22 per 1,000PY; [1.13-1.32], respectively. Between 2006-7 and 2016-17, the cohort accounted for 19 % of NSW opioid NFOD episodes, 12 % of sedative, 14 % of stimulant and 5 % of acute alcohol-related NFOD. CONCLUSIONS:Hospital stays due to NFOD are a relatively frequent occurrence among opioid-dependent people. There are clear differences in rates and substances involved by sex, age and over time. Evidence-based interventions that prevent overdose among people who are opioid dependent need to be delivered to scale, including widespread community provision of naloxone. |
Keywords: | Overdose; opioid; amphetamine; alcohol; sedative |
Rights: | © 2020 Elsevier B.V. All rights reserved. |
DOI: | 10.1016/j.drugalcdep.2020.108354 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1163961 http://purl.org/au-research/grants/nhmrc/1135991 |
Published version: | http://dx.doi.org/10.1016/j.drugalcdep.2020.108354 |
Appears in Collections: | Aurora harvest 8 Psychiatry publications |
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