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|Title:||Characterization of a gene encoding a cysteine-rich keratin associated protein synthesized late in rabbit hair follicle differentiation|
|Citation:||Differentiation, 1995; 58(3):227-232|
|Abstract:||Many different cysteine-rich proteins are synthesized during hair follicle differentiation, forming part of the interstitial matrix between bundles of intermediate filaments. We have isolated a rabbit gene (rKAP4L¹), a member of a multi gene family that encodes a small cysteine-rich hair keratin associated protein. This is the first complete gene sequence for this family. The rKAP4L gene is expressed in the cortex of rabbit pelage hair follicles at a late stage of hair follicle differentiation, well after the synthesis of the other major hair proteins, the intermediate filament and glycine/tyrosine-rich keratin associated proteins, has commenced. The protein contains 36 mol % cysteine, with a molecular size of 13593 daltons, and its sequence appears to be based on a pentapeptide repeat. It is predicted to adopt a folded conformation characterized by β-turns interspersed with short stretches of β-sheet or random coil|
|Keywords:||Hair; Animals; Sheep; Rabbits; Cysteine; Proteins; In Situ Hybridization; Chromosome Mapping; Cell Differentiation; Gene Expression; Amino Acid Sequence; Base Sequence; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Multigene Family; Molecular Sequence Data; Keratins|
|Description:||Copyright © 1999-2009 John Wiley & Sons, Inc. All Rights Reserved.|
|Appears in Collections:||Agriculture, Food and Wine publications|
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