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https://hdl.handle.net/2440/132786
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Type: | Journal article |
Title: | Dysregulated innate immune function in the aetiopathogenesis of idiopathic inflammatory myopathies |
Author: | Day, J. Otto, S. Proudman, S. Hayball, J.D. Limaye, V. |
Citation: | Autoimmunity Reviews, 2017; 16(1):87-95 |
Publisher: | Elsevier |
Issue Date: | 2017 |
ISSN: | 1568-9972 1873-0183 |
Statement of Responsibility: | Jessica Day, Sophia Otto, Susanna Proudman, John D.Hayball, Vidya Limaye |
Abstract: | The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of systemic muscle conditions that are believed to be autoimmune in nature. They have distinct pathological features, but the aetiopathogenesis of each subtype remains largely unknown. Recently, there has been increased interest in the complex role the innate immune system plays in initiating and perpetuating these conditions, and how this may differ between subtypes. This article summarises the traditional paradigms of IIM pathogenesis and reviews the accumulating evidence for disturbances in innate immune processes in these rare, but debilitating chronic conditions. |
Keywords: | Muscle, Skeletal Macrophages Immune System Animals Humans Myositis Chemokines Gene Expression Regulation Immunity, Innate |
Rights: | © 2016 Elsevier B.V. All rights reserved. |
DOI: | 10.1016/j.autrev.2016.09.019 |
Grant ID: | NHMRC |
Published version: | http://dx.doi.org/10.1016/j.autrev.2016.09.019 |
Appears in Collections: | Medicine publications |
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