Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/13280
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Type: Journal article
Title: Dynamic Expression of Ornithine Decarboxylane in Hair Growth
Author: Nancarrow, M.
Nesci, A.
Hynd, P.
Powell, B.
Citation: Mechanisms of Development, 1999; 84(1-2):161-164
Publisher: ELSEVIER SCIENCE BV
Issue Date: 1999
ISSN: 0925-4773
1872-6356
Abstract: Ornithine decarboxylase (ODC) is the key enzyme in the synthesis of polyamines, small cationic molecules believed to have a role in many cellular processes such as cell migration, proliferation and differentiation. We show that ODC expression is associated with cell proliferation and commitment in hair follicle development and hair growth. In embryonic epidermis, ODC is expressed in ectodermal cells at sites where follicles develop, and persists in cells at the leading edge of the follicle placode. ODC is abundantly expressed in proliferating bulb cells of anagen follicles, except for a pocket of cells at the base of the bulb. Entry of the follicle into catagen is accompanied by a down-regulation of ODC expression, which is not resumed until a new follicle is initiated. In vibrissae, ODC expression is more complex. ODC is expressed not only in the bulb but also in the hair shaft, presenting a striking biphasic pattern. Additionally, ODC is expressed in a group of outer root sheath cells in the vicinity of the follicle bulge, the putative site of hair follicle stem cells.
Keywords: Hair Follicle; Keratinocytes; Hair; Animals; Mice; Ornithine Decarboxylase; Histones; Cell Division; Gene Expression Regulation, Developmental
RMID: 0030003757
DOI: 10.1016/S0925-4773(99)00064-7
Appears in Collections:Agriculture, Food and Wine publications

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