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https://hdl.handle.net/2440/132823
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Type: | Journal article |
Title: | Associations of newborn brain magnetic resonance imaging with long-term neurodevelopmental impairments in very preterm children |
Author: | Anderson, P.J. Treyvaud, K. Neil, J.J. Cheong, J.L.Y. Hunt, R.W. Thompson, D.K. Lee, K.J. Doyle, L.W. Inder, T.E. |
Citation: | Journal of Pediatrics, 2017; 187:1-9 |
Publisher: | Elsevier |
Issue Date: | 2017 |
ISSN: | 0022-3476 1097-6833 |
Statement of Responsibility: | Peter J.Anderson, Karli Treyvaud, Jeffrey J.Neil, Jeanie L.Y.Cheong, Rodney W.Hunt, Deanne K.Thompson ... et al. |
Abstract: | Objective To determine the relationship between brain abnormalities on newborn magnetic resonance imaging (MRI) and neurodevelopmental impairment at 7 years of age in very preterm children. Study design A total of 223 very preterm infants (<30 weeks of gestation or <1250 g) born at Melbourne's Royal Women's Hospital had a brain MRI scan at term equivalent age. Scans were scored using a standardized system that assessed structural abnormality of cerebral white matter, cortical gray matter, deep gray matter, and cerebellum. Children were assessed at 7 years on measures of general intelligence, motor functioning, academic achievement, and behavior. Results One hundred eighty-six very preterm children (83%) had both an MRI at term equivalent age and a 7-year follow-up assessment. Higher global brain, cerebral white matter, and deep gray matter abnormality scores were related to poorer intelligence quotient (IQ) (Ps < .01), spelling (Ps < .05), math computation (Ps < .01), and motor function (Ps < .001). Higher cerebellum abnormality scores were related to poorer IQ (P = .001), math computation (P = .018), and motor outcomes (P = .001). Perinatal, neonatal, and social confounders had little effect on the relationships between the MRI abnormality scores and outcomes. Moderate-severe global abnormality on newborn MRI was associated with a reduction in IQ (−6.9 points), math computation (−7.1 points), and motor (−1.9 points) scores independent of the other potential confounders. Conclusions Structured evaluation of brain MRI at term equivalent is predictive of outcome at 7 years of age, independent of clinical and social factors. |
Keywords: | Brain Humans Magnetic Resonance Imaging Follow-Up Studies Child Infant Infant, Newborn Female Male Infant, Extremely Premature Neurodevelopmental Disorders |
Rights: | © 2017 Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.jpeds.2017.04.059 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/546519 http://purl.org/au-research/grants/nhmrc/1060733 http://purl.org/au-research/grants/nhmrc/237117 http://purl.org/au-research/grants/nhmrc/491209 http://purl.org/au-research/grants/nhmrc/1081288 http://purl.org/au-research/grants/nhmrc/1085754 http://purl.org/au-research/grants/nhmrc/1012236 http://purl.org/au-research/grants/nhmrc/1053787 |
Published version: | http://dx.doi.org/10.1016/j.jpeds.2017.04.059 |
Appears in Collections: | Paediatrics publications |
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