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https://hdl.handle.net/2440/132974
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Type: | Journal article |
Title: | Photochemistry and in vitro anticancer activity of Pt(IV)Re(I) conjugates |
Author: | Huang, Z. King, A.P. Lovett, J. Lai, B. Woods, J.J. Harris, H.H. Wilson, J.J. |
Citation: | Chemical Communications, 2021; 57(85):11189-11192 |
Publisher: | Royal Society of Chemistry |
Issue Date: | 2021 |
ISSN: | 1359-7345 1364-548X |
Statement of Responsibility: | Zhouyang Huang, A. Paden King, James Lovett, Barry Lai, Joshua J. Woods, Hugh H. Harris and Justin J. Wilson |
Abstract: | The photophysical and photochemical properties of two Pt(IV)Re(I) conjugates were studied via both experimental and computational methods. Both conjugates exhibit modest photocytotoxicity against ovarian cancer cells. X-ray fluorescence microscopy showed that Pt and Re colocalize in cells whether they had been irradiated or not. This work demonstrates the potential of photoactivated multilimetallic agents for combating cancer. |
Keywords: | Hela Cells Humans Ovarian Neoplasms Platinum Rhenium Antineoplastic Agents Photochemotherapy Spectrometry, X-Ray Emission Drug Screening Assays, Antitumor Computational Biology Apoptosis Cell Membrane Permeability Light Female Coordination Complexes Optical Imaging |
Rights: | This journal is © The Royal Society of Chemistry 2021 |
DOI: | 10.1039/d1cc04669a |
Grant ID: | http://purl.org/au-research/grants/arc/DP210102148 |
Published version: | http://dx.doi.org/10.1039/d1cc04669a |
Appears in Collections: | Biochemistry publications |
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