Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/132974
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Type: Journal article
Title: Photochemistry and in vitro anticancer activity of Pt(IV)Re(I) conjugates
Author: Huang, Z.
King, A.P.
Lovett, J.
Lai, B.
Woods, J.J.
Harris, H.H.
Wilson, J.J.
Citation: Chemical Communications, 2021; 57(85):11189-11192
Publisher: Royal Society of Chemistry
Issue Date: 2021
ISSN: 1359-7345
1364-548X
Statement of
Responsibility: 
Zhouyang Huang, A. Paden King, James Lovett, Barry Lai, Joshua J. Woods, Hugh H. Harris and Justin J. Wilson
Abstract: The photophysical and photochemical properties of two Pt(IV)Re(I) conjugates were studied via both experimental and computational methods. Both conjugates exhibit modest photocytotoxicity against ovarian cancer cells. X-ray fluorescence microscopy showed that Pt and Re colocalize in cells whether they had been irradiated or not. This work demonstrates the potential of photoactivated multilimetallic agents for combating cancer.
Keywords: Hela Cells
Humans
Ovarian Neoplasms
Platinum
Rhenium
Antineoplastic Agents
Photochemotherapy
Spectrometry, X-Ray Emission
Drug Screening Assays, Antitumor
Computational Biology
Apoptosis
Cell Membrane Permeability
Light
Female
Coordination Complexes
Optical Imaging
Rights: This journal is © The Royal Society of Chemistry 2021
DOI: 10.1039/d1cc04669a
Grant ID: http://purl.org/au-research/grants/arc/DP210102148
Published version: http://dx.doi.org/10.1039/d1cc04669a
Appears in Collections:Biochemistry publications

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