Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/133547
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Nogo-66 inhibits adhesion and migration of microglia via GTPase Rho pathway in vitro |
Author: | Yan, J. Zhou, X. Guo, J.J. Mao, L. Wang, Y.J. Sun, J. Sun, L.X. Zhang, L.Y. Zhou, X.F. Liao, H. |
Citation: | Journal of Neurochemistry, 2012; 120(5):721-731 |
Publisher: | Wiley-Blackwell |
Issue Date: | 2012 |
ISSN: | 0022-3042 1471-4159 |
Statement of Responsibility: | Jun Yan, Xiao Zhou, Jing-Jing Guo, Lei Mao, Yi-Jin Wang, Jing Sun ... et al. |
Abstract: | Nogo-66 is a 66-amino-acid-residue extracellular domain of Nogo-A, which plays a key role in inhibition neurite outgrowth of central nervous system through binding to the Nogo-66 receptor (NgR) expressed on the neuron. Recent studies have confirmed that NgR is also expressed on the surface of macrophages/microglia in multiple sclerosis, but its biological effects remain unknown. In the present study, our results demonstrated that Nogo-66 triggered microglia anti-adhesion and inhibited their migration in vitro, which was mediated by NgR. We also assessed the roles of small GTP (glycosyl phosphatidylinositol)-binding proteins of the Rho family as the downstream signal transducers on the microglia adhesion and mobility induced by Nogo-66. The results showed that Nogo-66 activated RhoA and reduced the activity of Cdc42 in the meanwhile, which further triggered the anti-adhesion and migration inhibition effects to microglia. Nogo-66 inhibited microglia polarization and membrane protrusion formation, thus might eventually contribute to the decreasing capability of cell mobility. Taken together, the Nogo-66/NgR pathway may modulate neuroinflammation via mediating microglia adhesion and migration in addition to its role in neurons. Better understanding the relationship between Nogo-66/NgR and neuroinflammation may help targeting NgR for treating central nervous system diseases related with inflammation. |
Keywords: | Nogo Receptor 1 |
Rights: | © 2011 The Authors. © 2011 International Society for Neurochemistry |
DOI: | 10.1111/j.1471-4159.2011.07619.x |
Published version: | http://dx.doi.org/10.1111/j.1471-4159.2011.07619.x |
Appears in Collections: | Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.