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https://hdl.handle.net/2440/134446
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Type: | Journal article |
Title: | Long-term intrathecal administration of morphine vs. baclofen: differences in CSF glycoconjugate profiles using multiglycomics |
Author: | Moh, E.S.X. Nishtala, K. Iqbal, S. Staikopoulos, V. Kapur, D. Hutchinson, M.R. Packer, N.H. |
Citation: | Glycobiology, 2022; 32(1):50-59 |
Publisher: | Oxford University Press (OUP) |
Issue Date: | 2022 |
ISSN: | 0959-6658 1460-2423 |
Statement of Responsibility: | Edward S.X. Moh, Krishnatej Nishtala, Sameera Iqbal, Vasiliki Staikopoulos, Dilip Kapur, Mark R. Hutchinson, and Nicolle H. Packer |
Abstract: | Opioid use for treatment of persistent pain has increased dramatically over the past two decades, but it has not resulted in improved pain management outcomes. To understand the molecular mechanisms of opioids, molecular signatures that arise from opioid exposure are often sought after, using various analytical methods. In this study, we performed proteomics, and multiglycomics via sequential analysis of polysialic acids, glycosaminoglycans, N-glycans and O-glycans, using the same cerebral spinal fluid (CSF) sample from patients that had long-term (>2 years), intrathecal morphine or baclofen administered via an indwelling pump. Proteomics and N-glycomics signatures between the two treatment groups were highly conserved, while significant differences were observed in polysialic acid, heparan sulfate glycosaminoglycan and O-glycan profiles between the two treatment groups. This represents the first study to investigate the potential relationships between diverse CSF conjugated glycans and long-term intrathecal drug exposure. The unique changes, observed by a sequential analytical workflow, reflect previously undescribed molecular effects of opioid administration and pain management. |
Keywords: | CSF; GAGs; morphine; multiglycomics; polysialic acid |
Description: | Published: 09 September 2021 |
Rights: | © The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com |
DOI: | 10.1093/glycob/cwab098 |
Grant ID: | http://purl.org/au-research/grants/arc/CE140100003 http://purl.org/au-research/grants/arc/FT180100565 |
Published version: | http://dx.doi.org/10.1093/glycob/cwab098 |
Appears in Collections: | Medicine publications |
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