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https://hdl.handle.net/2440/134493
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Type: | Journal article |
Title: | Psychometric properties of the EQ-5D-3L in South Australia: a multi-method non-preference-based validation study |
Author: | Zakershahrak, M. Ribeiro Santiago, P.H. Sethi, S. Haag, D. Jamieson, L. Brennan, D. |
Citation: | Current Medical Research and Opinion, 2022; 38(5):673-685 |
Publisher: | Taylor & Francis |
Issue Date: | 2022 |
ISSN: | 0300-7995 1473-4877 |
Statement of Responsibility: | Mehrsa Zakershahrak, Pedro Henrique Ribeiro Santiago, Sneha Sethi, Dandara Haag, Lisa Jamieson and David Brennan |
Abstract: | OBJECTIVE: Although HRQoL tools such as the EQ-5D-3L are significant in determining health status, these measures have not been validated in general populations in Australia. This study aims to psychometrically validate the EQ-5D-3L in a large population sample in Australia for the first time. METHODS: The EQ-5D-3L was included in the Dental Care and Oral Health study (DCOHS), conducted in a South Australian population sample. The participants were 23-91 years old, and 44.1% were male. The EQ-5D-3L was responded to on a three-point rating scale ("none"/"no", "some" and "extremely"/"unable"/"confined"). We employed the area under the receiver operating characteristic curve (AUROC) to evaluate whether the EQ-5D-3L total score could identify participants with diagnosed diseases and mental health disorders. Psychometric validation of the EQ-5D-3L investigated dimensionality with Exploratory Graph Analysis, model fit, floor/ceiling effects and criterion validity. RESULTS: The EQ-5D-3L comprised two dimensions, Activities and Symptoms. According to Root Mean Squared Error of Approximation (RMSEA) (<.05) and Comparative Fit Index (CFI) (>.950), the 2-dimensional structure showed excellent model fit with good reliability for the Activities subscale (Ωc = 0.80 - 95% CI [0.77, 0.83]), and poor reliability for the Symptom subscale (Ωc =0.56 - 95% CI [0.53, 0.58]). The EQ-5D-3L showed adequate reliability (Ωc= 0.70 - 95% CI [0.67, 0.72]). The EQ-5D-3L showed good discrimination for diagnosed diseases (ranging from 64.3% to 86.3%). Floor/ceiling effects were observed across all items. The EQ-5D-3L total score discriminated between respondents who were experiencing health conditions (e.g. cancer, cardiovascular disease, stroke) from healthy individuals. DISCUSSION: Despite the ceiling effects, the EQ-5D-3L displayed good psychometric properties as an HRQoL measure and discriminated between health states in the general South Australian population. Further research should investigate the psychometric properties of the EQ-5D-5L in South Australia and whether an increased number of response categories can mitigate the observed ceiling effects. |
Keywords: | Health status Health-related quality of life Psychometrics Quality-adjusted life-years |
Description: | Published online: 06 Feb 2022. |
Rights: | © 2022 Informa UK Limited, trading as Taylor & Francis Group |
DOI: | 10.1080/03007995.2022.2031941 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1031310 |
Published version: | http://dx.doi.org/10.1080/03007995.2022.2031941 |
Appears in Collections: | Dentistry publications |
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