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https://hdl.handle.net/2440/134574
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Type: | Journal article |
Title: | Bacterial adaptation strategies to host-derived fatty acids |
Author: | Kengmo Tchoupa, A. Eijkelkamp, B.A. Peschel, A. |
Citation: | Trends in Microbiology, 2022; 30(3):241-253 |
Publisher: | Elsevier BV |
Issue Date: | 2022 |
ISSN: | 0966-842X 1878-4380 |
Statement of Responsibility: | Arnaud Kengmo Tchoupa, Bart A. Eijkelkamp, and Andreas Peschel |
Abstract: | Fatty acids (FAs) are potent antimicrobials which hold great promise as viable alternatives or complements to conventional antibiotics. Intriguingly, bacteria are well equipped to use environmental FAs as energy sources and/or building blocks for their membrane lipids. Furthermore, these microbes display a wide array of mechanisms to prevent or mitigate FA toxicity. In this review we discuss strategies that bacteria use to thrive despite extensive exposure to host-derived antimicrobial FAs. We also highlight the altered response of these FA-adapted bacteria to antibiotics. Given the ubiquitous nature of FAs in various host environments, deciphering bacterial adaptation strategies to FAs is of prime importance. This knowledge may pave the way for a rational design of FA-based combination therapies with antibiotics. |
Keywords: | Antimicrobial fatty acids; bacterial pathogens; host–microbe interactions; adaptation strategies; antimicrobial resistance |
Rights: | © 2021 Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.tim.2021.06.002 |
Grant ID: | http://purl.org/au-research/grants/arc/DP210100553 http://purl.org/au-research/grants/nhmrc/GNT1159752 |
Published version: | http://dx.doi.org/10.1016/j.tim.2021.06.002 |
Appears in Collections: | Microbiology and Immunology publications |
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