Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/135853
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Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Zur Bonsen, A.B. | - |
dc.contributor.author | Peralta, R.A. | - |
dc.contributor.author | Fallon, T. | - |
dc.contributor.author | Huang, D.M. | - |
dc.contributor.author | George, J.H. | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Angewandte Chemie International Edition, 2022; 61(34):1-10 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.issn | 1521-3773 | - |
dc.identifier.uri | https://hdl.handle.net/2440/135853 | - |
dc.description | Version of record online: July 14, 2022 | - |
dc.description.abstract | Structurally unique natural products pose biosynthetic puzzles whose solution can inspire new chemical reactions. Herein, we propose a unified biosynthetic pathway towards some complex meroterpenoids—the hyperireflexolides, biyoulactones, hybeanones and hypermonones. This hypothesis led to the discovery of uncatalyzed, intramolecular carbonyl-ene reactions that are spontaneous at room temperature. We also developed an anionic cascade reaction featuring an α-hydroxy-β-diketone rearrangement and an intramolecular aldol reaction to access four distinct natural product scaffolds from a common intermediate. | - |
dc.description.statementofresponsibility | Andreas B. zur Bonsen, Ricardo A. Peralta, Thoma sFallon, David M. Huang, and Jonathan H. George | - |
dc.language.iso | en | - |
dc.publisher | Wiley | - |
dc.rights | © 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCHGmbH.This is an open access article under the terms of the Creative Commons Attribution License,which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | - |
dc.source.uri | http://dx.doi.org/10.1002/anie.202203311 | - |
dc.subject | Biomimetic Synthesis; Carbonyl-Ene Reaction; Cascade Reactions; Natural Products; Rearrangement | - |
dc.title | Intramolecular Tricarbonyl-Ene Reactions and α-Hydroxy-β-Diketone Rearrangements Inspired by the Biosynthesis of Polycyclic Polyprenylated Acylphloroglucinols | - |
dc.title.alternative | Intramolecular Tricarbonyl-Ene Reactions and alpha-Hydroxy-beta-Diketone Rearrangements Inspired by the Biosynthesis of Polycyclic Polyprenylated Acylphloroglucinols | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1002/anie.202203311 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP200102964 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Zur Bonsen, A.B. [0000-0001-9111-3876] | - |
dc.identifier.orcid | Peralta, R.A. [0000-0001-7573-2968] | - |
dc.identifier.orcid | Fallon, T. [0000-0002-6495-5282] | - |
dc.identifier.orcid | Huang, D.M. [0000-0003-2048-4500] | - |
dc.identifier.orcid | George, J.H. [0000-0002-7330-2160] | - |
Appears in Collections: | Chemistry publications |
Files in This Item:
File | Description | Size | Format | |
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hdl_135853.pdf | Published version | 5.88 MB | Adobe PDF | View/Open |
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