Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/136901
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Type: Journal article
Title: Admixture has obscured signals of historical hard sweeps in humans
Author: Souilmi, Y.
Tobler, R.
Johar, A.
Williams, M.
Grey, S.T.
Schmidt, J.
Teixeira, J.C.
Rohrlach, A.
Tuke, J.
Johnson, O.
Gower, G.
Turney, C.
Cox, M.
Cooper, A.
Huber, C.D.
Citation: Nature Ecology and Evolution, 2022; 6(12):2003-2015
Publisher: Springer Science and Business Media LLC
Issue Date: 2022
ISSN: 2397-334X
2397-334X
Statement of
Responsibility: 
Yassine Souilmi, Raymond Tobler, Angad Johar, Matthew Williams, Shane T. Grey, Joshua Schmidt, João C. Teixeira, Adam Rohrlach, Jonathan Tuke, Olivia Johnson, Graham Gower, Chris Turney, Murray Cox, Alan Cooper, and Christian D. Huber
Abstract: The role of natural selection in shaping biological diversity is an area of intense interest in modern biology. To date, studies of positive selection have primarily relied on genomic datasets from contemporary populations, which are susceptible to confounding factors associated with complex and often unknown aspects of population history. In particular, admixture between diverged populations can distort or hide prior selection events in modern genomes, though this process is not explicitly accounted for in most selection studies despite its apparent ubiquity in humans and other species. Through analyses of ancient and modern human genomes, we show that previously reported Holocene-era admixture has masked more than 50 historic hard sweeps in modern European genomes. Our results imply that this canonical mode of selection has probably been underappreciated in the evolutionary history of humans and suggest that our current understanding of the tempo and mode of selection in natural populations may be inaccurate.
Keywords: Animals
Hominidae
Humans
Genomics
Genome, Human
Selection, Genetic
Biological Evolution
Description: Published online: December 2022
Rights: © The Author(s) 2022 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons. org/licenses/by/4.0/.
DOI: 10.1038/s41559-022-01914-9
Grant ID: http://purl.org/au-research/grants/arc/FL140100260
http://purl.org/au-research/grants/arc/DE180100883
http://purl.org/au-research/grants/arc/DE190101069
Published version: http://dx.doi.org/10.1038/s41559-022-01914-9
Appears in Collections:Biochemistry publications

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