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Type: Journal article
Title: Endothelial cell dysfunction: Implications for the pathogenesis of peripheral artery disease
Author: Kavurma, M.M.
Bursill, C.
Stanley, C.P.
Passam, F.
Cartland, S.P.
Patel, S.
Loa, J.
Figtree, G.A.
Golledge, J.
Aitken, S.
Robinson, D.A.
Citation: Frontiers in Cardiovascular Medicine, 2022; 9:1-15
Publisher: Frontiers Media SA
Issue Date: 2022
ISSN: 2297-055X
Statement of
Mary M. Kavurma, Christina Bursill, Christopher P. Stanley, Freda Passam, Siân P. Cartland, Sanjay Patel, Jacky Loa, Gemma A. Figtree, Jonathan Golledge, Sarah Aitken, and David A. Robinson
Abstract: Peripheral artery disease (PAD) is caused by occluded or narrowed arteries that reduce blood flow to the lower limbs. The treatment focuses on lifestyle changes, management of modifiable risk factors and vascular surgery. In this review we focus on how Endothelial Cell (EC) dysfunction contributes to PAD pathophysiology and describe the largely untapped potential of correcting endothelial dysfunction. Moreover, we describe current treatments and clinical trials which improve EC dysfunction and offer insights into where future research efforts could be made. Endothelial dysfunction could represent a target for PAD therapy.
Keywords: angiogenesis
endothelial cell dysfunction
peripheral artery disease (PAD)
vascular tone
Rights: © 2022 Kavurma, Bursill, Stanley, Passam, Cartland, Patel, Loa, Figtree, Golledge, Aitken and Robinson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
DOI: 10.3389/fcvm.2022.1054576
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